SAB4702141

Monoclonal Anti-CD1a APC produced in mouse

• Sinónimos: FCB6, HTA1, Leu-6, T6
• Código UNSPSC: 12352203

Propiedades

• conjugado: Allophycocyanin conjugate
• Nivel de calidad: 100
• tipo de anticuerpo: primary antibodies
• clon: SK9, monoclonal
• formulario: buffered aqueous solution
• reactividad de especies: human
• técnicas: flow cytometry: suitable
• isotipo: IgG2bκ
• Nº de acceso UniProt: P06126
• temp. de almacenamiento: 2-8°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... CD1A(909)

Descripción

Descripción general

CD1a, together with CD1b and c, belongs to group 1 of CD1 glycoproteins. These proteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. Unlike CD1b, CD1a is excluded from late endosomal compartments and instead traffics independently in the recycling pathway of the early endocytic system, and CD1a antigen presentation is independent upon vesicular acidification.

Especificidad

The mouse monoclonal antibody SK9 recognizes an extracellular epitope of CD1a (T6), a 49 kDa polypeptide associated with beta2-microglobulin expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells and some T cell leukemias and lymphomas.

Inmunógeno

Human thymocytes

Forma física

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Nota de preparación

Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Almacenamiento y estabilidad

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Otras notas

The antibody solution should be gently mixed before use.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable