SAB4702130

Monoclonal Anti-CD22, purified produced in mouse

• Sinónimos: SIGLEC-2, SIGLEC2
• Código UNSPSC: 12352203

Propiedades

• conjugado: unconjugated
• Nivel de calidad: 100
• tipo de anticuerpo: primary antibodies
• clon: S-HCL-1, monoclonal
• formulario: buffered aqueous solution
• reactividad de especies: human
• concentración: 1 mg/ml
• técnicas: flow cytometry: suitable
• isotipo: IgG2bκ
• Nº de acceso UniProt: P20273
• temp. de almacenamiento: 2-8°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... CD22(933)

Descripción

Descripción general

CD22, also known as Siglec-2 (sialic acid-binding immunoglobulin-like lectin-2) is a transmembrane glycoprotein binding alpha2,6-linked sialic acid-bearing ligands. Intracellular domain of CD22 recruits protein tyrosine phosphatase SHP-1 through the immunoreceptor tyrosine-based inhibitory motifs (ITIMs), thus setting a treshold for B cell receptor-mediated activation. CD22 also regulates B-cell response by involvement in controlling the CD19/CD21-Src-family protein tyrosine kinase amplification pathway and CD40 signaling. CD22 exhibits hallmarks of clathrin-mediated endocytic pathway.

Especificidad

The mouse monoclonal antibody S-HCL-1 (also known as S-HCL1) recognizes an extracellular epitope of CD22 (BL-CAM), a 130 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed in the cytoplasm of pro-B and pre-B lymphocytes, and on the surface of mature and activated B lymphocytes; it is lost on plasma cells, peripheral blood T lymphocytes, granulocytes and monocytes.

Inmunógeno

Whole hairy cell leukemia cells and membrane preparation

Forma física

Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide

Nota de preparación

Purified by protein-A affinity chromatography.

Almacenamiento y estabilidad

Store at 2-8°C. Do not freeze.

Otras notas

The antibody solution should be gently mixed before use.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): nwg
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable