SAB4702100

Monoclonal Anti-Myeloperoxidase PE produced in mouse

• Sinónimos: MPO
• Código UNSPSC: 12352203

Propiedades

• conjugado: phycoerythrin (R-PE) conjugate
• Nivel de calidad: 100
• tipo de anticuerpo: primary antibodies
• clon: MPO421-8B2, monoclonal
• formulario: buffered aqueous solution
• reactividad de especies: human
• técnicas: flow cytometry: suitable
• isotipo: IgG1
• Nº de acceso UniProt: P05164
• temp. de almacenamiento: 2-8°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... MPO(4353)

Descripción

Descripción general

Myeloperoxidase (MPO) is a heme enzyme that is localized in azurophilic (primary) granules of myeloid cells and its synthesis occurs at an early stage of differentiation. The mature myeloperoxidase is a tetramer composed of two light (12 kDa) and two heavy (60 kDa) chains. This enzyme uses hydrogen peroxide to oxidize numerous substrates, including serotonin, melatonin or chloride, to produce reactive free radicals that contribute to immune reactions of myeloid cells against pathogens. Myeloperoxidase functions not only in host defense by mediating efficient microbial killing but also can contribute to progressive tissue damage in chronic inflammatory states such as atherosclerosis or acute pancreatitis.

Especificidad

The mouse monoclonal antibody MPO421-8B2 recognizes human myeloperoxidase, a heme protein present in intracellular granules of myeloblasts, neutrophils and monocytes. It is a marker of acute myelogenous leukemias and acute lymphoblastic leukemias.

Inmunógeno

Human myeloperoxidase

Forma física

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Nota de preparación

Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Almacenamiento y estabilidad

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Otras notas

The antibody solution should be gently mixed before use.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable