SAB4702014

Monoclonal Anti-BCL2 FITC produced in mouse

• Sinónimos: Bcl-2, PPP1R50
• Código UNSPSC: 12352203

Propiedades

• conjugado: FITC conjugate
• Nivel de calidad: 100
• tipo de anticuerpo: primary antibodies
• clon: Bcl-2/100, monoclonal
• formulario: buffered aqueous solution
• reactividad de especies: human
• técnicas: flow cytometry: suitable
• isotipo: IgG1
• Nº de acceso UniProt: P10415
• temp. de almacenamiento: 2-8°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... BCL2(596)

Descripción

Descripción general

Bcl2 (B cell chronic lymphatic leukemia protein 2) is a proto-oncogen, which can contribute to tumorigenesis by counteracting apoptosis in various cell types. The anti-apoptotic effect of Bcl2 is performed by its interactions with suppressors and agonists of cell death and under physiological conditions it is regulated by proteolytic processing and phosphorylation. Bcl2 expression can be detected mainly in lymphoid tissues and in the basal cells of epithelial tissues. It is also a marker that can help in classification of lymphoproliferative diseases and in prognostics of some epithelial neoplasms.

Especificidad

The mouse monoclonal antibody Bcl-2/100 recognizes Bcl2, a 26 kDa intracellular protooncogen with anti-apoptotic effect, expressed in outer mitochondrial membrane, endoplasmic reticulum and nuclear envelope.

Inmunógeno

Synthetic peptide corresponding to the amino acids 41-54 of human Bcl2

Forma física

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Nota de preparación

Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Almacenamiento y estabilidad

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Otras notas

The antibody solution should be gently mixed before use.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable