SAB4700120

Monoclonal Anti-CD20, azide free antibody produced in mouse

clone MEM-97, purified immunoglobulin, buffered aqueous solution

• Sinónimos: Anti-MS4A1
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: mouse
• conjugado: unconjugated
• forma del anticuerpo: purified immunoglobulin
• tipo de anticuerpo: primary antibodies
• clon: MEM-97, monoclonal
• formulario: buffered aqueous solution
• reactividad de especies: bovine, human, pig
• concentración: 1 mg/mL
• técnicas: flow cytometry: suitable
• isotipo: IgG1
• Nº de acceso NCBI: NM_021950.3
• Nº de acceso UniProt: P11836
• Condiciones de envío: wet ice
• temp. de almacenamiento: 2-8°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... MS4A1(931)

Descripción

Descripción general

Cluster of differentiation 20 (CD20), also referred to as membrane spanning 4-domains A1 (MS4A1), is expressed on the surface of human B lymphocytes and on a small subset of T cells. The 33-35kDa, non-glycosylated protein has four membrane-spanning domains with both the amino and carboxy termini of the protein localized to the cytoplasm and a short 43 residue-extracellular segment. It is part of the membrane-spanning 4A gene family. The gene encoding MS4A1 is localized on human chromosome 11q12-13.

Inmunógeno

Raji human Burkitt′s lymphoma cell line

Aplicación

The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 10 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

Acciones bioquímicas o fisiológicas

Cluster of differentiation 20 (CD20) participates in the development and cell cycle progression in B-cells. It has been found to interact with proteins like adapter protein p75/80, CD40 and major histocompatibility complex class II proteins (MHC II). It may participate in Ca2+ influx across plasma membranes, maintenance of Ca2+ concentration and activation of B-cells. CD20 activates Src leading to rapid phosphorylation of phospholipase C-γ1 (PLC-γ1) and PLC-γ2, in turn activating caspase-3 signaling of apoptosis. Overexpression of the gene has been associated with the development of primary cutaneous T-cell lymphomas (CTCL).

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forma física

Solution in azide free phosphate buffered saline, pH 7.4; 0.2 um filter sterilized.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable