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SAB4503785

Sigma-Aldrich

Anti-phospho-Trk B (pTyr515) antibody produced in rabbit

affinity isolated antibody

Sinónimos:

Anti-DEE58, Anti-EIEE58, Anti-GP145-TrkB, Anti-OBHD, Anti-TRKB, Anti-trk-B

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

formulario

buffered aqueous solution

mol peso

antigen 91 kDa

reactividad de especies

human, rat, mouse

concentración

~1 mg/mL

técnicas

ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

Nº de acceso NCBI

Q16620

Nº de acceso UniProt

Q16620

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

phosphorylation (pTyr515)

Información sobre el gen

human ... NTRK2(4915)

Descripción general

NTRK2 (neurotrophic tyrosine kinase receptor type 2) is also known as TRKB (tropomyosin receptor kinase B). It belongs to the Trk family of neurotrophin receptors. It is located on human chromosome 9q21.32.

Inmunógeno

The antiserum was produced against synthesized peptide derived from human Trk B around the phosphorylation site of Tyr515.

Immunogen Range: 481-530

Aplicación

Anti-phospho-Trk B (pTyr515) antibody has been used in western blotting.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Acciones bioquímicas o fisiológicas

In NB (neuroblastoma), NTRK2 (neurotrophic tyrosine kinase receptor type 2) controls the favorable and unfavorable clinical actions. It also controls the roles of glutamate receptor and synaptic plasticity in the amygdala.

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Case Report: Next generation sequencing identifies a NAB2-STAT6 fusion in Glioblastoma.
Diamandis P, et al.
Diagnostic Pathology, 11(1), 13-13 (2016)
A common NTRK2 variant is associated with emotional arousal and brain white-matter integrity in healthy young subjects.
Spalek K, et al.
Translational Psychiatry, 6(3), e758-e758 (2017)
Micaela Lucarelli et al.
Molecular neurobiology, 60(9), 5395-5410 (2023-06-14)
Niemann-Pick type C1 (NPC1) disease is a lysosomal lipid storage disorder due to mutations in the NPC1 gene resulting in the accumulation of cholesterol within the endosomal/lysosomal compartments. The prominent feature of the disorder is the progressive Purkinje cell degeneration
Stephanie M Muscat et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 43(1), 155-172 (2022-11-18)
Perioperative neurocognitive disorders (PNDs) are characterized by confusion, difficulty with executive function, and episodic memory impairment in the hours to months following a surgical procedure. Postoperative cognitive dysfunction (POCD) represents such impairments that last beyond 30 d postsurgery and is
Yan Liu et al.
Neuropharmacology, 144, 337-344 (2018-11-09)
NSI-189 Phosphate, (4-benzylpiperazin-1-yl)-[2-(3-methyl-butylamino)pyridin-3-yl] methanone is a new chemical entity under development for the treatment of MDD, based upon preclinical data demonstrating stimulation of neurogenesis of human hippocampus-derived neural stem cells in vitro and in mouse hippocampus in vivo. Previous studies
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