SAB4503170
Anti-FZD3 antibody produced in rabbit
affinity isolated antibody
Sinónimos:
FZD3, Frizzled-3, Fz-3, hFz3
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About This Item
Productos recomendados
origen biológico
rabbit
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
formulario
buffered aqueous solution
mol peso
antigen 76 kDa
reactividad de especies
mouse, human
concentración
~1 mg/mL
técnicas
ELISA: 1:1000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... FZD3(7976)
Categorías relacionadas
Descripción general
Anti-FZD3 Antibody detects endogenous levels of total FZD3 protein.
The FZD3 (frizzled class receptor 3) gene is mapped to human chromosome 8p21.1. It codes for a receptor with seven-transmembrane domain and is expressed in human melanocytes.
Inmunógeno
The antiserum was produced against synthesized peptide derived from human FZD3.
Immunogen Range: 141-190
Immunogen Range: 141-190
Aplicación
Anti-FZD3 antibody produced in rabbit has been used in immunohistochemistry.
Acciones bioquímicas o fisiológicas
Mutation in FZD3 (frizzled class receptor 3) gene might account for Hirschsprung disease, a birth defect lacking the intrinsic ganglion cells of the lower intestine. FZD3 regulates the growth of longitudinal axon tracts in the central nervous system. FZD3 mediates the dynamics of axon within the enteric, sympathetic and peripheral nervous systems. FZD3 regulates planar cell polarity. Abnomal FZD3 gene methylation causes chromatin structure modifications, associated with congenital hydrocephalus.
Características y beneficios
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Forma física
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
nwg
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Jie Xie et al.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 66, 24-32 (2017-12-03)
Previous studies have demonstrated that both Wnt5a and Sonic hedgehog (Shh) are involved in regulating the pathfinding of descending serotonergic (5-HT, 5-hydroxytryptamine) axons in an opposite manner in the brainstem. Shh and Wnt signaling pathways interact to guide post-crossing commissural
Ateeque Siddique et al.
Canadian journal of physiology and pharmacology, 96(2), 208-214 (2017-12-16)
The cellular mechanisms that induce calcific aortic stenosis are yet to be unraveled. Wnt signaling is increasingly being considered as a major player in the disease process. However, the presence of Wnt Frizzled (Fzd) receptors and co-receptors LRP5 and 6
Celsr3 and Fzd3 in axon guidance.
Chai G, et al.
The International Journal of Biochemistry & Cell Biology, 64, 11-14 (2015)
The roles of Frizzled-3 and Wnt3a on melanocyte development: in vitro studies on neural crest cells and melanocyte precursor cell lines.
Chang CH, et al.
Journal of Dermatological Science, 75(2), 100-108 (2014)
Impaired methylation modifications of FZD3 alter chromatin accessibility and are involved in congenital hydrocephalus pathogenesis.
Wang L, et al.
Brain Research, 1569, 48-56 (2014)
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