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SAB4502541

Sigma-Aldrich

Anti-CD45 antibody produced in rabbit

affinity isolated antibody

Sinónimos:

L-CA, LY-5, Leukocyte common antigen precursor, Leukocyte common antigen variant 4 precursor, Lymphocyte common antigen Ly-5

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

formulario

buffered aqueous solution

mol peso

antigen 147 kDa

reactividad de especies

rat, mouse, human

concentración

~1 mg/mL

técnicas

ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100

Nº de acceso NCBI

P08575

Nº de acceso UniProt

P08575

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... PTPRC(5788)

Descripción general

Anti-CD45 antibody detects endogenous levels of total CD45 protein.
The CD45 (cluster of differentiation 45) gene is mapped to human chromosome 1q31.3-q32.1. It codes for a type I transmembrane protein and is expressed in nucleated hematopoietic cells along within its precursors. The protein consists of a varying extracellular domain and a highly conserved intracellular domain.

Inmunógeno

The antiserum was produced against synthesized peptide derived from human CD45.

Immunogen Range: 981-1030

Aplicación

Anti-CD45 antibody produced in rabbit has been used in:
  • immunohistochemistry staining
  • immunofluorescence staining
  • immunostaining

Acciones bioquímicas o fisiológicas

The Cluster of differentiation 45 (CD45) facilitates the regulation of lymphocyte signaling and SRC family kinase Lck. This protein participates in the polymorphism in several mammalian species.
The protein encoded by CD45 (cluster of differentiation 45) is a prototypic receptor and exhibits phosphatase activity. CD45 is found to control T-cell mediated BCR-signaling.

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

nwg

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Sigma-Aldrich

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T-helper signals restore B-cell receptor signaling in autoreactive anergic B cells by upregulating CD45 phosphatase activity.
Szodoray P
The Journal of Allergy and Clinical Immunology, 138(3), 839-851 (2016)
The soluble cytoplasmic tail of CD45 (ct-CD45) in human plasma contributes to keep T cells in a quiescent state.
Puck A
European Journal of Immunology, 47(1), 193-205 (2017)
Milja Arponen et al.
Frontiers in physiology, 13, 1035516-1035516 (2022-12-17)
Bone is an active tissue that undergoes constant remodeling. Bone formation requires energy and one of the energy sources of bone-forming osteoblasts is glucose, which is transported inside the cells via glucose transporters. However, the role of class I glucose
Sathish Babu Vasamsetti et al.
Immunity, 49(1), 93-106 (2018-07-01)
There is a growing body of research on the neural control of immunity and inflammation. However, it is not known whether the nervous system can regulate the production of inflammatory myeloid cells from hematopoietic progenitor cells in disease conditions. Myeloid
Ondřej Kodet et al.
International journal of molecular sciences, 22(13) (2021-07-21)
Therapy targeting immune checkpoints represents an integral part of the treatment for patients suffering from advanced melanoma. However, the mechanisms of resistance are responsible for a lower therapeutic outcome than expected. Concerning melanoma, insufficient stimulation of the immune system by
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