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SAB4501536

Sigma-Aldrich

Anti-IKK-β antibody produced in rabbit

affinity isolated antibody

Sinónimos:

I-κ-B kinase 2, I-κ-B-kinase β, IKK-β, IKK-B, IKK2

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About This Item

Número MDL:
MFCD02263521
Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

formulario

buffered aqueous solution

mol peso

antigen 86 kDa

reactividad de especies

mouse, rat, human

concentración

~1 mg/mL

técnicas

ELISA: 1:10000
immunohistochemistry: 1:50-1:100

Nº de acceso NCBI

O14920

Nº de acceso UniProt

O14920

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

Información sobre el gen

human ... IKBKB(3551)

Descripción general

IKBKB codes for the enzyme, inhibitor of nuclear factor kappa B kinase subunit β (IKK-β/I-K-B kinase 2). It is mapped to human chromosome 8p11.

Inmunógeno

The antiserum was produced against synthesized peptide derived from human IKK-beta.

Immunogen Range: 166-215

Aplicación

Anti-IKK-β antibody produced in rabbit has been used in western blotting.

Acciones bioquímicas o fisiológicas

Inhibitor of nuclear factor kappa B kinase subunit β (IKK-β) acts as a regulator of cell survival and inflammatory response. It promotes cell survival and metabolic adaptation during glutamine deprivation. IKK-β phosphorylates inhibitor of KB proteins and facilitates their degradation. This further leads to the activation of nuclear factor KB (NF-KB) transcription factors. It also phosphorylates β-catenin, tuberous sclerosis 1 (TSC1) and Bcl-2-associated death promoter (BAD).

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

nwg

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Adrenomedullin inhibits osteoclast differentiation through the suppression of receptor activator of nuclear factor-KB ligand-induced nuclear factor-KB activation in glucocorticoid-induced osteoporosis.
Liu Y, et al.
Experimental and Therapeutic Medicine, 14(5), 4009-4016 (2017)
IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3.
Michael A. R, et al.
Genes & Development, 30(16), 1837- 1851 (2016)
Canonical nuclear factor KB pathway links tumorigenesis of synchronous mantle-cell lymphoma, clear-cell renal-cell carcinoma, and GI stromal tumor.
Guo R, et al.
Journal of Clinical Oncology, 29(10), e257-e261 (2011)
Deficiency of innate and acquired immunity caused by an IKBKB mutation.
Pannicke U, et al.
The New England Journal of Medicine, 369(26), 2504-2514 (2013)
Yuanxin Liu et al.
Experimental and therapeutic medicine, 14(5), 4009-4016 (2017-10-27)
The current study aimed to improve the understanding on the association between adrenomedullin and osteoporosis in mice with glucocorticoid-induced osteoporosis. Bone resorption and osteoporosis-associated indexes, including maximum load, stiffness, energy to failure, ultimate strength, elastic modulus, post-yield displacement and post-yield

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