SAB4301310

Anti-phospho-PEK/PERK (pThr⁹⁸¹) antibody produced in rabbit

affinity isolated antibody

• Sinónimos: E2AK3, EIF2AK3, PEK, PERK
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: buffered aqueous solution
• mol peso: 125 kDa
• reactividad de especies: human
• concentración: 1.0 mg/mL
• técnicas: immunohistochemistry: 1:50-1:100
• isotipo: IgG
• nº de acceso: NP_004827.4.
• Nº de acceso UniProt: Q9NZJ5
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: phosphorylation (pThr981)
• Información sobre el gen: human ... EIF2AK3(9451)

Descripción

Descripción general

Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK)/EIF2AK3 (eukaryotic translation initiation factor 2 α kinase 3) is a type I transmembrane protein, located on ER (endoplasmic reticulum). It is a member of the eIF2α kinase subfamily. This gene is located on human chromosome 2p. EIF2AK3 has 16 exons and is made of cytoplasmic and kinase domains.

Especificidad

The antibody detects endogenous levels of PEK/PERK only when phosphorylated at threonine 981.

Inmunógeno

Peptide sequence around phosphorylation site of threonine 981(A-R-H(p)-T-G) derived from Human PEK/PERK.

Acciones bioquímicas o fisiológicas

Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) helps to detect the protein-folding imbalance created by endoplasmic reticulum (ER) stress. EIF2AK3 works as an endoplasmic reticulum (ER) stress sensor to modulate global protein synthesis. Mutation in EIF2AK3 gene results in Wolcott-rallison syndrome.

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable