SAB4301136
Anti-c-Myc Tag antibody produced in rabbit
affinity isolated antibody
Sinónimos:
Myc Tag Antibody, Myc Tag Antibody - Anti-c-Myc Tag antibody produced in rabbit, c- Myc epitope Tag
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.43
Productos recomendados
origen biológico
rabbit
Nivel de calidad
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
formulario
buffered aqueous solution
mol peso
55 kDa
concentración
1 mg/mL
técnicas
western blot: 1:1000-1:5000 (Cell Lysate)
isotipo
IgG
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Descripción general
c-Myc (v-myc avian myelocytomatosis viral oncogene homolog) is a transcription factor, which is coded by MYC gene. It was first described as a homolog of an avian retroviral oncogene. It belongs to the family of transcription factors which are characterized by basic region helix-loop-helix/leucine zipper. Along with N-Myc and L-Myc, it forms the MYC proto-oncogene family. It forms a heterodimer with MAX, and this heterodimer binds to the E-boxes/CACGTG sequence motif on DNA. This gene is localized to human chromosome 8q24.
Especificidad
The antibody detects transfected proteins contanining c-Myc Tag.
Inmunógeno
Synthetic peptide: C-EQKLISEEDL conjugated with KLH.
Aplicación
Anti-c-Myc Tag antibody produced in rabbit has been used in western blotting.
Acciones bioquímicas o fisiológicas
v-myc avian myelocytomatosis viral oncogene homolog belongs to MYC family. When overexpressed, these proteins can delay the resolution of DNA lesions and cause DNA double-strand breaks (DSBs) and genome instability. This transcription factor MYC helps in regulating long noncoding RNAs (lncRNAs), which has been implicated in cancer cell proliferation and tumorigenesis. Its overexpression is also associated with various cancers, and in particular B cell lymphomas. Elevated expression of c-MYC inhibits the ability of B cell lymphomas to functionally present antigens/peptides to CD4+ T cells. It is associated with Burkitt lymphoma and a group of diffuse large B-cell lymphoma (DLBCL).
Características y beneficios
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Forma física
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Los clientes también vieron
Elevation of c-MYC Disrupts HLA Class II-mediated Immune Recognition of Human B-cell Tumors.
Jason M G, et al.
Journal of Immunology, 194(4), 1434-1445 (2016)
Suniti Misra et al.
Frontiers in cell and developmental biology, 9, 649862-649862 (2021-06-22)
Discoveries in the identification of transcription factors, growth factors and extracellular signaling molecules have led to the detection of downstream targets that modulate valvular tissue organization that occurs during development, aging, or disease. Among these, matricellular protein, periostin, and cytoskeletal
MYC impairs resolution of site-specific DNA double-strand breaks repair.
Ambrosio S, et al.
Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis, 774, 6-13 (2015)
Clinicopathologic and prognostic significance of c-MYC copy number gain in lung adenocarcinomas.
Seo A N, et al.
British Journal of Cancer, 110(11), 2688-2688 (2014)
Role of MYC-regulated long noncoding RNAs in cell cycle regulation and tumorigenesis.
Kim T, et al.
Journal of the National Cancer Institute, 107(4), dju505-dju505 (2015)
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