SAB4300830

Anti-UCN antibody produced in rabbit

affinity isolated antibody

• Sinónimos: UI, UROC
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: buffered aqueous solution
• reactividad de especies: rat, human, mouse
• concentración: 0.7 mg/mL
• técnicas: immunohistochemistry: 1:25- 1:100
• isotipo: IgG
• nº de acceso: NP_003344.1
• Nº de acceso UniProt: P55089
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... UCN(7349)

Descripción

Descripción general

Urocortin (UCN) belongs to the hypothalamic hormone corticotrophin-releasing factor (CRF) family. UCN has 45% homology to CRF. UCN is expressed in brain, placenta, lymphocytes and heart. In human chromosome, the gene UCN is localized on 2p23.3.

Especificidad

The antibody detects endogenous levels of total UCN protein.

Inmunógeno

Synthetic peptide corresponding to residues near the C terminal of human urocortin

Aplicación

Anti-UCN antibody produced in rabbit has been used in immunohistochemical analysis.

Acciones bioquímicas o fisiológicas

Urocortin (UCN1) is a key protein involved in regulating hypothalamic-pituitary-adrenal axis and modulating stress responses. Ucn1 is associated with both G-protein coupled CRF receptors and CRF binding proteins. UCN increases the heart rate, cardiac output, and coronary blood flow according to the dosage. UCN protects cardiac myocytes from cell death due to stress. Ucn upregulates p42/p44 mitogen activated protein kinase (MAPK) signalling pathway and protects the heart from reperfusion injury. High levels of Ucn mRNA have been observed in the Edinger−Westphal (EW) nucleus, associated with alcohol and drug addiction. Ucn delays the gastric emptying and reduces the food intake and thus regulates the body weight. Ucn enhances anxiogenic-like or stress-like effect. Ucn causes degranulation of mast cells and increases vascular permeability in response to stress. Ucn is found to be associated with stress induced atopic dermatitis or psoriasis.

Características y beneficios

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Forma física

Rabbit IgG in pH7.3 PBS, 0.05% NaN₃, 50% Glycerol.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable