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SAB4300525

Sigma-Aldrich

Anti-GAP43 (Ab-41) antibody produced in rabbit

affinity isolated antibody

Sinónimos:

Anti-B-50 antibody produced in rabbit, Anti-PP46 antibody produced in rabbit, Anti-growth associated protein 43 antibody produced in rabbit

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About This Item

Número MDL:
MFCD00164594
Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

formulario

buffered aqueous solution

mol peso

~43 kDa

reactividad de especies

rat, human, mouse

concentración

1 mg/mL

técnicas

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000

isotipo

IgG

secuencia del inmunógeno

(Q-A-S-F-R)

Nº de acceso NCBI

NP_001123536.1

Nº de acceso UniProt

P17677

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... GAP43(2596)

Categorías relacionadas

Descripción general

Growth associated protein-43 (GAP-43) is a phosphoprotein associated with membrane. It is located on chromosome 3q13. During neural development and axonal regeneration, GAP43 is upregulated in neuronal growth cones and Schwann cell precursors.

Inmunógeno

Peptide sequence around aa. 38-43 (Q-A-S-F-R), according to the protein GAP43.

Acciones bioquímicas o fisiológicas

Growth associated protein-43 (GAP-43) participates in neurite outgrowth, growth cone navigation, neurotransmission, stabilization of axonal branches and synaptic plasticity. In humans and mice, GAP43 is recognized as a possible gene for autism and autistic-like disorders.

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Descripción de destino

GAP43 encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Forma física

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Víctor Carriel et al.
Journal of tissue engineering and regenerative medicine, 11(2), 553-563 (2014-08-02)
Nerve conduits are promising alternatives for repairing nerve gaps; they provide a close microenvironment that supports nerve regeneration. In this sense, histological analysis of axonal growth is a determinant to achieve successful nerve regeneration. To evaluate this process, the most-used
Ryan L O'Hare Doig et al.
Frontiers in molecular neuroscience, 13, 85-85 (2020-07-17)
Reducing the extent of secondary degeneration following spinal cord injury (SCI) is necessary to preserve function, but treatment options have thus far been limited. A combination of the ion channel inhibitors Lomerizine (Lom), YM872 and oxATP, to inhibit voltage-gated Ca2+
Jesús Chato-Astrain et al.
Neural regeneration research, 18(8), 1852-1856 (2023-02-09)
Growth-associated protein 43 plays a key role in neurite outgrowth through cytoskeleton remodeling. We have previously demonstrated that structural damage of peripheral nerves induces growth-associated protein 43 upregulation to promote growth cone formation. Conversely, the limited regenerative capacity of the
Jesús Chato-Astrain et al.
Frontiers in cellular neuroscience, 12, 501-501 (2019-01-11)
The regenerative capability of peripheral nerves is very limited, and several strategies have been proposed to increase nerve regeneration. In the present work, we have analyzed the in vivo usefulness of a novel nanostructured fibrin-agarose bio-artificial nerve substitute (Nano) used
A rare 3q13.31 microdeletion including GAP43 and LSAMP genes
Gimelli S, et al.
Molecular Cytogenetics, 6(1), 52-52 (2013)
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