SAB4300400

Anti-PRKD1 (Ab-910) antibody produced in rabbit

affinity isolated antibody

• Sinónimos: Anti-PKC-MU antibody produced in rabbit, Anti-PKCM antibody produced in rabbit, Anti-PKD antibody produced in rabbit, Anti-PRKCM antibody produced in rabbit, Anti-protein kinase D1 antibody produced in rabbit
• Número MDL: MFCD03455823
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: buffered aqueous solution
• mol peso: ~115 kDa
• reactividad de especies: human, mouse
• concentración: 1 mg/mL
• técnicas: western blot: 1:500-1:1000
• isotipo: IgG
• secuencia del inmunógeno: (R-V-S-I-L)
• Nº de acceso NCBI: NP_002733.2
• Nº de acceso UniProt: Q15139
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... PRKD1(5587)

Descripción

Descripción general

PRKD1 gene encodes PKD1 (protein kinase D1), that belongs to the protein kinase D family. It is a serine/threonine kinase, which is expressed in cells of the normal mammary gland. The PRKD1 gene promoter has a great CpG island covering 1.2kb, including the transcription start site and the entire exon 1.

Inmunógeno

Peptide sequence around aa. 908-912 (R-V-S-I-L), according to the protein PRKD1.

Acciones bioquímicas o fisiológicas

PRKD1 (Protein kinase D 1) is a negative modulator of cell migration . It plays an important role in cell adhesion, cell migration, vesicle transport, cell survival , signal transduction, membrane trafficking and immune function. It preserves the epithelial phenotype by inhibiting epithelial-to-mesenchymal transition.

Características y beneficios

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Descripción de destino

Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress through activation of NF-kappa-B.

Forma física

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable