SAB4200425

Anti-COG1 (N-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• Sinónimos: Anti-CDG2G, Anti-COG complex subunit 1, Anti-LDLB, Anti-component of oligomeric golgi complex 1, Anti-conserved oligomeric Golgi complex subunit 1, Anti-low density lipoprotein receptor defect B complementing
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: buffered aqueous solution
• mol peso: antigen ~110 kDa
• reactividad de especies: rat, mouse, human
• concentración: ~1.0 mg/mL
• técnicas: western blot: 2.5-5.0 μg/mL using whole extracts of human HepG2 and rat PC12 cells.
• Nº de acceso UniProt: Q8WTW3
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... COG1(9382) ; mouse ... Cog1(16834) ; rat ... Cog1(303652)

Descripción

Descripción general

The conserved oligomeric Golgi complex 1 (COG1) protein is a member of the conserved oligomeric Golgi (COG) complex. COG complex is an evolutionarily conserved multi-subunit protein complex. COG complex contains eight subunits organized in two heterotrimeric groups, COG-2-COG3-COG4 and COG5-COG6-COG7, which are linked by the dimeric group formed by COG1 and COG8. The COG1 gene is located on the human chromosome at 17q25.1.

Especificidad

Anti-COG1 (N-terminal) recognizes human and rat COG1.

Inmunógeno

peptide corresponding to the N-terminal region of human COG1, conjugated to KLH. The corresponding sequence is identical in mouse, rat, monkey and bovine COG1.

Aplicación

Anti-COG1 (N-terminal) antibody produced in rabbit may be used in immunoblotting.

Acciones bioquímicas o fisiológicas

The conserved oligomeric Golgi complex 1 (COG1) protein is needed for normal Golgi function. It is required for steps in the normal medial and trans-Golgi-associated processing of glycoconjugates. It also plays a role in the organization of the Golgi-localized complex. In humans, mutations in the COG subunit cause novel types of congenital disorders of glycosylation.

Forma física

solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Almacenamiento y estabilidad

For continuous use, store at 2-8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable