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Merck
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SAB4200412

Sigma-Aldrich

Anti-PLAUR/uPAR antibody, Mouse monoclonal

enhanced validation

clone PL231, purified from hybridoma cell culture

Sinónimos:

Anti-CD87, Anti-Plasminogen activator urokinase receptor, Anti-UPAR, Anti-URKR, Monoclonal Anti-PLAUR/uPAR antibody produced in mouse

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

mouse

Nivel de calidad

200

conjugado

unconjugated

forma del anticuerpo

purified from hybridoma cell culture

tipo de anticuerpo

primary antibodies

clon

PL231, monoclonal

formulario

buffered aqueous solution

mol peso

antigen ~55 kDa

reactividad de especies

monkey, rat, canine, human, mouse

validación mejorada

recombinant expression
Learn more about Antibody Enhanced Validation

concentración

~1.0 mg/mL

técnicas

indirect immunofluorescence: suitable
western blot: 4.0-8.0 μg/mL using extracts of HL-60 cells

isotipo

IgG1

Nº de acceso UniProt

Q03405

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... PLAUR(5329)

Categorías relacionadas

Descripción general

Plasminogen activator, urokinase receptor (PLAUR) is a well-characterized receptor for matrix-degrading proteases. It is encoded by the gene mapped to human chromosome 19q13.31.

Inmunógeno

peptide corresponding to a sequence at the C-terminus of human PLAUR/uPAR.

Aplicación

Monoclonal Anti-PLAUR/uPAR antibody produced in mouse has been used in Western blotting (WB).

Acciones bioquímicas o fisiológicas

Plasminogen activator, urokinase receptor (PLAUR) plays a vital role in tumor cell invasion, angiogenesis and metastasis. It acts as a key regulator of cell-surface plasminogen activator. It is implicated in various normal and pathological processes. Elevated expression of the gene has been observed in various types of cancers, including head and neck squamous cell carcinoma (HNSCC). Thus, it is considered as an potent biomarker for targeted imaging or therapy. Upregulated expression of PLAUR leads to the progression of kidney disease in children.

Forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Opcional

Referencia del producto
Descripción
Precios

Código de clase de almacenamiento

10 - Combustible liquids

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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John H Rossmeisl et al.
OncoTargets and therapy, 10, 2077-2085 (2017-04-27)
The expression of the urokinase plasminogen activator receptor (uPAR), a glycosylphosphatidylinositol-anchored protein family member, and the activity of its ligand, urokinase-type plasminogen activator (uPA), have been associated with the invasive and metastatic potentials of a variety of human brain tumors
Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds.
Chang H Y, et al.
PLoS Biology, 2(2), 7-7 (2004)
Assignment of the Urokinase-Type Plasminogen Activator Receptor Gene (PLAUR) to Chromosome 1 9q 13.1 -q 13.2
B?rglum A D, et al.
American Journal of Human Genetics, 50(3), 492-492 (1992)
Yue Lang et al.
Cell death & disease, 10(6), 401-401 (2019-05-28)
Urokinase plasminogen activator receptor (uPAR) is upregulated in podocytes of glomerular diseases and crucially mediates podocyte injury through integrin β3 (ITGB3). We previously showed that the miR-30 family maintains podocyte structure and function by inhibiting injurious calcineurin signaling through nuclear
SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer.
Harris N L E, et al.
Oncogene, 36(30), 4288-4288 (2017)
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