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Merck
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SAB4200216

Sigma-Aldrich

Monoclonal Anti-Caveolin-1 antibody produced in mouse

enhanced validation

clone CAV1, tissue culture supernatant

Sinónimos:

Anti-BSCL3, Anti-CAV1, Anti-CGL3, Anti-MSTP085, Anti-VIP21, Anti-caveolae protein, 22kDa

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About This Item

Número MDL:
MFCD01633097
Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

mouse

conjugado

unconjugated

forma del anticuerpo

tissue culture supernatant

tipo de anticuerpo

primary antibodies

clon

CAV1, monoclonal

formulario

buffered aqueous solution

mol peso

antigen 22 kDa

reactividad de especies

rat, human, mouse

validación mejorada

independent
Learn more about Antibody Enhanced Validation

técnicas

immunohistochemistry: suitable
indirect immunofluorescence: 1:1000-1:2000 using human HUVEC or mouse 3T3 cells.
western blot: suitable

isotipo

IgM

Nº de acceso UniProt

Q03135

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... CAV1(857)
mouse ... Cav1(12389)
rat ... Cav1(25404)

Categorías relacionadas

Descripción general

Caveolin-1 (CAV1) is a multifunctional scaffolding protein, that has three exons. It is located on human chromosome 7q31.

Inmunógeno

synthetic peptide corresponding to a sequence at the N-terminal of human caveolin-1, conjugated to KLH.

Aplicación

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Monoclonal Anti-Caveolin-1 antibody has been used in western blot analysis.

Acciones bioquímicas o fisiológicas

Caveolin-1 may play a major role in the growth and evolution of cancer. It participates in glucose metabolism. It may also participate in angiogenesis. Cav-1 helps to control the expression of glucose transporters.

Forma física

Culture supernatant solution containing 15 mM sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Opcional

Referencia del producto
Descripción
Precios

Código de clase de almacenamiento

10 - Combustible liquids

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Joshua Chuck Harrell et al.
Cancer research, 67(21), 10582-10591 (2007-11-03)
The lymphatic system is a common avenue for the spread of breast cancer cells and dissemination through it occurs at least as frequently as hematogenous metastasis. Approximately 75% of primary breast cancers are estrogen receptor (ER) positive and the majority
Margaret E Tome et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 38(12), 2209-2222 (2018-10-23)
P-glycoprotein (PgP) is the major drug efflux pump in human cerebral microvessels. PgP prevents pathogens, toxins and therapeutic drugs from entering the CNS. Understanding the molecular regulation of PgP activity will suggest novel mechanisms to improve CNS drug delivery. Previously
Expression of flotilin-2 and acrosome biogenesis are regulated by MiR-124 during spermatogenesis
Wu Y, et al.
PLoS ONE, 10(8), e0136671-e0136671 (2015)
Ye Xiong et al.
Oncotarget, 8(15), 24902-24914 (2017-02-18)
As the most prevalent primary brain tumor, gliomas are highly metastatic, invasive and are characteristic of high levels of glial cell-line derived neurotrophic factor (GDNF). GDNF is an important factor for invasive glioma cell growth; however, the underlying mechanism involved
Genes encoding human caveolin-1 and-2 are co-localized to the D7S522 locus (7q31. 1), a known fragile site (FRA7G) that is frequently deleted in human cancers
Engelman J A, et al.
Febs Letters, 436(3), 403-410 (1998)
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