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Merck

SAB4200068

Sigma-Aldrich

Anti-PSPC1 (N-terminal) antibody produced in rabbit

enhanced validation

~1.0 mg/mL, affinity isolated antibody

Sinónimos:

Anti-PSP1, Anti-Paraspeckle protein 1

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

formulario

buffered aqueous solution

mol peso

antigen ~59 kDa

reactividad de especies

human

validación mejorada

independent
Learn more about Antibody Enhanced Validation

concentración

~1.0 mg/mL

técnicas

indirect immunofluorescence: 1.2-2.5 μg/mL using paraformaldehyde fixed HEK-293T cells
western blot (chemiluminescent): 0.5-1 μg/mL using lysates of HEK-293T cells

Nº de acceso UniProt

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... PSPC1(55269)

Categorías relacionadas

Descripción general

Paraspeckle protein 1 (PSP1/ PSPC1) has two isoforms, α and β. PSPC1 belongs to the Drosophila melanogaster behavior, human splicing (DBHS) protein family.

Aplicación

Anti-PSPC1 (N-terminal) antibody produced in rabbit may be used in several immunochemical techniques including immunoblotting (~59 kDa) and immunofluorescence. It has also been used in RNA immunoprecipitation (RIP) experiment.

Acciones bioquímicas o fisiológicas

Paraspeckle protein 1(PSP1/ PSPC1) is implicated in the regulation of nuclear receptors such as the progesterone receptor and the thyroid receptor, and in a wide range of processes such as transcription, splicing, and RNA metabolism. It acts as a marker for paraspeckles, which are ribonucleoprotein bodies found in the interchromatin space of mammalian cell nuclei that are often located adjacent to splicing speckles.

Forma física

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

The DBHS proteins SFPQ, NONO and PSPC1: a multipurpose molecular scaffold
Knott GJ, et al.
Nucleic Acids Research, 44(9), 3989-4004 (2016)
Circadian RNA expression elicited by 3?-UTR IRAlu-paraspeckle associated elements
Torres M, et al.
eLife, 5(9), e14837-e14837 (2016)
P54nrb forms a heterodimer with PSP1 that localizes to paraspeckles in an RNA-dependent manner
Fox AH, et al.
Molecular Biology of the Cell, 16(11), 5304-5315 (2005)
Luisa Gabriel et al.
Journal of cell science, 134(10) (2021-05-27)
Zα domains recognize the left-handed helical Z conformation of double-stranded nucleic acids. They are found in proteins involved in the nucleic acid sensory pathway of the vertebrate innate immune system and host evasion by viral pathogens. Previously, it has been
Manon Torres et al.
eLife, 5 (2016-07-22)
Paraspeckles are nuclear bodies form around the long non-coding RNA, Neat1, and RNA-binding proteins. While their role is not fully understood, they are believed to control gene expression at a post-transcriptional level by means of the nuclear retention of mRNA

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