SAB3500252

Anti-TIM-1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Sinónimos: Anti-T cell immunoglobulin and mucin domain containing protein 1
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: buffered aqueous solution
• mol peso: predicted mol wt 40 kDa
• reactividad de especies: human, mouse
• técnicas: immunofluorescence: suitable; immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• Nº de acceso NCBI: NP_036338
• Nº de acceso UniProt: Q96D42
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... HAVCR1(26762)

Descripción

Descripción general

Hepatitis A virus cellular receptor 1 (HAVCR1) or T-cell immunoglobulin and mucin protein (TIM-1) is a type 1 transmembrane glycoprotein. The protein is found in the apical membrane of cells. It is expressed in the kidney, testis and activated CD4⁺ T-cells. It possesses a six-cysteine immunoglobulin-like domain, a T/SP rich domain and two N-glycosylation sites. The TIM-1 gene is localized on human chromosome 5q33.2.

Inmunógeno

TIM-1 antibody was raised against a 16 amino acid peptide from near the amino terminus of human TIM-1.

Aplicación

Anti-TIM-1 antibody produced in rabbit has been used in immunofluorescence.

Acciones bioquímicas o fisiológicas

Hepatitis A virus cellular receptor 1 (HAVCR1) regulates susceptibility to human immunodeficiency virus-1 (HIV-1) infection. It is upregulated in injured kidneys. HAVCR1 inhibits the activation of the Ga12 G-protein by blocking its association to GTP. Polymorphisms in the protein have been associated with immune dysfunction.

Características y beneficios

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Ligadura / enlace

The action of this antibody can be blocked using blocking peptide SBP3500252.

Forma física

Supplied in PBS with 0.02% sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable