SAB3500051

Anti-SHOC2 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Sinónimos: Anti-Leucine-rich repeat protein SHOC-2, Anti-Ras-binding protein Sur-8, Anti-SOC2
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: buffered aqueous solution
• reactividad de especies: rat, mouse, human
• técnicas: immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• Nº de acceso NCBI: NP_031399
• Nº de acceso UniProt: Q9UQ13
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... SHOC2(8036)

Descripción

Descripción general

Leucine-rich repeat protein SHOC-2 is a widely expressed protein composed almost entirely of leucine-rich repeats (LRR), with a lysine-rich sequence at the amino terminus and is cytoplasmically localized. SHOC2 acts as a positive modulator of the RAS-MAPK signaling cascade.

Inmunógeno

SHOC2 antibody was raised against a 21 amino acid peptide near the amino terminus of human SHOC2.

Acciones bioquímicas o fisiológicas

Leucine-rich repeat protein SHOC2 participates in protein binding / transferase activity in the fibroblast growth factor receptor signaling pathway and Ras protein signal transduction. SHOC2, together with protein phosphatase 1c (PP1c), forms a highly specific M-Ras effector complex and is essential for the activation of MAPK pathway by growth factors. Furthermore, in tumor cells with Ras gene mutations, inhibition of SHOC2 expression inhibits MAPK, but not PI3K activity. The SHOC2-PP1c holoenzyme provides an attractive therapeutic target for inhibition of the MAPK pathway in cancer. Recent studies show that aberrantly acquired N-myristoylation of SHOC2 causes human disease Noonan-like syndrome with loose anagen hair.

Características y beneficios

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Ligadura / enlace

The action of this antibody can be blocked using blocking peptide SBP3500051.

Forma física

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable