SAB3500027

Anti-ZBED1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Sinónimos: Anti-ALTE, Anti-DREF, Anti-TRAMP, Anti-Zinc finger BED-type domain containing 1, Anti-hDREF
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: buffered aqueous solution
• reactividad de especies: human, mouse
• técnicas: indirect ELISA: suitable; western blot: suitable
• Nº de acceso NCBI: AAH15030
• Nº de acceso UniProt: O96006
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... ZBED1(9189)

Descripción

Inmunógeno

ZBED1 antibody was raised against a 15 amino acid peptide from near the center of human ZBED1.

Características y beneficios

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Descripción de destino

ZBED1, also known as DREF, is the human homolog of the Drosophila protein DREF, a transcriptional regulatory factor required for expression of genes involved in DNA replication and cell proliferation. RNA interference (RNAi) experiments targeting ZBED1 RNA resulted in the inhibition of S phase entry and reduction of histone H1 mRNA in HeLa cells, suggesting that ZBED1 also plays a role in cell proliferation in human cells. At least 22 ribosomal proteins (RPs) possess ZBED1 binding sites in their promoters; anti-ZBED1 RNAi also resulted in decreased RP gene expression. Immunoprecipitation analyses have shown that ZBED1 self-associates in vivo via a carboxyl-terminal hATC domain, and this self-association is required for nuclear localization and DNA binding. This antibody is predicted to have no cross-reactivity to ZBED2 or ZBED3.

Ligadura / enlace

The action of this antibody can be blocked using blocking peptide SBP3500027.

Forma física

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable