SAB1306611

ANTI-LC3 (APG8B) (N-TERM) antibody produced in rabbit

purified immunoglobulin, buffered aqueous solution

• Sinónimos: Autophagy-related protein LC3 B, Autophagy-related ubiquitin-like modifier LC3 B, MAP1ALC3, MAP1LC3B, Microtubule-associated proteins 1A/1B light chain 3B
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: purified immunoglobulin
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: buffered aqueous solution
• mol peso: 14688 Da
• reactividad de especies: human, rat
• técnicas: immunofluorescence: 1:100; immunohistochemistry: 1:50-1:100; western blot: 1:1000
• Nº de acceso NCBI: NP_073729.1
• Nº de acceso UniProt: Q9GZQ8
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... MAP1LC3B(81631)

Descripción

Descripción general

The gene LC3B or MAP1LC3B (microtubule associated protein 1 light chain 3 beta) is a homolog of the ATG8 gene, an autophagy-related gene in yeast. The encoded protein is called pro-MAP1LC3B, a pro-form that is cleaved by ATG4 to produce a cytosolic form called MAP1LC3B-I.

Acciones bioquímicas o fisiológicas

MAP1LC3B-I (microtubule associated protein 1 light chain 3 beta-I) conjugates with MAP1LC3B-II before being inserted into both inner and outer membranes of the growing autophagic vesicle during autophagy. The cellular distribution and processing of MAP1LC3B facilitates monitoring of autophagy. Cells that lack MAP1LC3B are found to be defective in the formation of autophagic vesicles, with altered phenotypes associated with the role of autophagy in energy homeostasis and removal of protein aggregates. It can serve as an autophagic marker.

Forma física

Supplied in PBS with 0.09% (W/V) sodium azide

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable