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Merck
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SAB1306582

Sigma-Aldrich

Anti-Ubiquitin antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Sinónimos:

Polyubiquitin-C, UBC, Ubiquitin

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

100

forma del anticuerpo

IgG fraction of antiserum

tipo de anticuerpo

primary antibodies

clon

polyclonal

formulario

buffered aqueous solution

mol peso

77039 Da

reactividad de especies

human

técnicas

immunofluorescence: 1:10-1:50
immunohistochemistry: 1:50-1:100
western blot: 1:1000

Nº de acceso UniProt

P0CG48

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... UBC(7316)

Descripción general

Ubiquitin, also known as ubiquitin C (UBC), is a globular protein, encoded by the gene mapped to human chromosome 12q24.31. The encoded protein consists of 76 amino acids.

Inmunógeno

a synthetic peptide between 36-66 amino acids of human Ubiquitin, which is in the Ubiquitin-like 1 domain

Aplicación

Anti-ubiquitin antibody produced in rabbit has been used in western blotting.

Acciones bioquímicas o fisiológicas

Ubiquitin plays a major role in protein degradation. Ubiquitin-mediated degradation of regulatory proteins has been implicated in the regulation of various processes, such as cell-cycle progression, signal transduction, transcriptional regulation, receptor down-regulation and endocytosis. Aberrations in the ubiquitin-mediated pathways contribute to malignant transformation.

Forma física

Supplied in PBS with 0.09% (W/V) sodium azide

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Opcional

Referencia del producto
Descripción
Precios

Código de clase de almacenamiento

10 - Combustible liquids

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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The VHL short variant involves in protein quality control
Liu Y, et al.
Gene, 589, 63-71 (2016)
Localization of the human UBC polyubiquitin gene to chromosome band 12q24.3.
Board PG, et al.
Genomics, 12, 639-642 (1992)
Jia-Hua Qu et al.
eLife, 12 (2024-01-22)
Our prior study (Tarasov et al., 2022) discovered that numerous adaptive mechanisms emerge in response to cardiac-specific overexpression of adenylyl cyclase type 8 (TGAC8) which included overexpression of a large number of proteins. Here, we conducted an unbiased phosphoproteomics analysis
A Hershko et al.
Annual review of biochemistry, 67, 425-479 (1998-10-06)
The selective degradation of many short-lived proteins in eukaryotic cells is carried out by the ubiquitin system. In this pathway, proteins are targeted for degradation by covalent ligation to ubiquitin, a highly conserved small protein. Ubiquitin-mediated degradation of regulatory proteins
Ubiquitin recognition by the proteasome
Saeki Y, et al.
Journal of Biochemistry, 161, 113-124 (2017)
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