SAB1300445

Anti-TRRAP (center) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Sinónimos: Anti-TRRAP protein
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• conjugado: unconjugated
• forma del anticuerpo: IgG fraction of antiserum
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: buffered aqueous solution
• reactividad de especies: human
• técnicas: immunohistochemistry: 1:50-1:100; indirect ELISA: 1:1000
• Nº de acceso NCBI: NP_003487
• Nº de acceso UniProt: Q9Y4A5
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... TRRAP(8295)

Descripción

Descripción general

TRRAP, a member of the TRA1 subfamily of the PI3/PI4 kinase family, is an adapter protein found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. It plays a central role in MYC (c-Myc) transcription activation, and also participates in cell transformation by MYC. TRRAP is required for p53/TP53-, E2F1- and E2F4-mediated transcription activation, and is also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. It likely performs by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Although probably not required in the steps following histone acetylation in processes of transcription activation, it may be required for the mitotic checkpoint and normal cell cycle progression. It is a component of various HAT complexes, including the PCAF, TFTC, TIP60 STAGA and BAF53 complexes. The PI3K/PI4K domain of this nuclear protein is required for the recruitment of HAT complexes, and the MYC-dependent transactivation. Although it is strongly related to the PI3/PI4-kinase family, it lacks the typical motifs that constitute the catalytic site of PI3/PI4-kinase proteins, and lacks such activity.

Inmunógeno

TRRAP (Q9Y6H4, 186-221)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human TRRAP.

Forma física

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): nwg
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable