S9129

Somatostatin

≥97% (HPLC), powder

• Sinónimos: Growth hormone release inhibiting factor, SRIF, Somatostatin-14, Somatotropin release inhibiting factor
• Fórmula empírica (notación de Hill): C₇₆H₁₀₄N₁₈O₁₉S₂
• Número de CAS: 38916-34-6
• Peso molecular: 1637.88
• Beilstein: 6436064
• Número CE: 254-186-5
• Número MDL: MFCD00076762
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24899825
• NACRES: NA.32

Propiedades

• Nivel de calidad: 200
• Análisis: ≥97% (HPLC)
• formulario: powder
• temp. de almacenamiento: −20°C
• cadena SMILES: [H]N1[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc6ccccc6)C(=O)N[C@@H]([C@@H](C)O)C(=O)NC(CO)C(=O)N[C@@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](C)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C1=O)C(O)=O
• InChI: 1S/C76H104N18O19S2/c1-41(79)64(100)82-37-61(99)83-58-39-114-115-40-59(76(112)113)92-72(108)57(38-95)91-75(111)63(43(3)97)94-71(107)54(33-46-23-11-6-12-24-46)90-74(110)62(42(2)96)93-66(102)51(28-16-18-30-78)84-69(105)55(34-47-36-81-49-26-14-13-25-48(47)49)88-68(104)53(32-45-21-9-5-10-22-45)86-67(103)52(31-44-19-7-4-8-20-44)87-70(106)56(35-60(80)98)89-65(101)50(85-73(58)109)27-15-17-29-77/h4-14,19-26,36,41-43,50-59,62-63,81,95-97H,15-18,27-35,37-40,77-79H2,1-3H3,(H2,80,98)(H,82,100)(H,83,99)(H,84,105)(H,85,109)(H,86,103)(H,87,106)(H,88,104)(H,89,101)(H,90,110)(H,91,111)(H,92,108)(H,93,102)(H,94,107)(H,112,113)/t41-,42+,43+,50-,51-,52-,53-,54-,55-,56-,57?,58-,59-,62-,63-/m0/s1
• Clave InChI: NHXLMOGPVYXJNR-FQSIDJEASA-N
• Información sobre el gen: human ... SSTR1(6751) , SSTR2(6752) , SSTR3(6753) , SSTR4(6754) , SSTR5(6755)

Descripción

Amino Acid Sequence

Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys

Descripción general

Somatostatin (SST) is a peptide.

Somatostatin is expressed in endocrine cells and nerve fibers of the gastrointestinal tract. It is also expressed in other tissues.

Aplicación

Somatostatin has been used:

• as a standard antigen to detect antibodies in an indirect enzyme-linked immunosorbent assay (ELISA) method
• to study the effect of somatostatin on oxytocin release during pregnancy in rats
• to test the specificity of the avidin-biotinylated horseradish peroxidase immunocytochemical procedure to visualize somatostatin-immunoreactive (SS-IR) neurons

Acciones bioquímicas o fisiológicas

Somatostatin (SST) performs several functions like anti-proliferation, pro-apoptosis and anti-migration. Somatostatin performs physiological activities with the help of various G protein-coupled receptor subtypes (SST receptor (SSTR)-1, SSTR2A, SSTR2B, and SSTR3-5).

Somatostatin regulates the secretion of hormones and bioactive peptides. It acts as an inhibitor in the digestive tract by inhibiting gastrin release. In the pancreatic islets, it inhibits glucagon and insulin release. Somatostatin and its synthetic analogs have been used in the treatment of neuroendocrine tumors.

Otras notas

Lyophilized from 0.1% TFA in H2O

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)