S0191

Sonic Hedgehog Peptide from mouse

≥97% (SDS-PAGE), recombinant, expressed in E. coli, Fused to a histidine tag at the C-terminus, lyophilized powder

• Sinónimos: Shh
• Número MDL: MFCD03792594
• Código UNSPSC: 12352202
• NACRES: NA.32

Propiedades

• origen biológico: mouse
• Nivel de calidad: 200
• recombinante: expressed in E. coli
• Análisis: ≥97% (SDS-PAGE)
• formulario: lyophilized powder
• potencia: 0.4-3.0 μg/mL ED₅₀
• mol peso: predicted mol wt 20 kDa
• envase: pkg of 25 μg
• condiciones de almacenamiento: avoid repeated freeze/thaw cycles
• impurezas: <1 EU/μg
• Nº de acceso UniProt: Q62226
• temp. de almacenamiento: −20°C
• Información sobre el gen: mouse ... Shh(20423)

Descripción

Descripción general

Sonic hedgehog (Shh) is a morphogenic glycoprotein. The gene encoding it is localized on mouse chromosome 5.

Aplicación

Sonic hedgehog peptide from mouse has been used for neural differentiation.

Acciones bioquímicas o fisiológicas

Cell signaling peptide involved in embryonic morphogenic development of several tissues including Hensen′s node, the notochord, and the neural tube.

Sonic hedgehog (Shh) has a role in fracture healing and regeneration. The protein associates with its receptor Patched (Ptc-1), de-represses Smoothened (Smo) and activates the Gli family of transcription factors. Mutations in the Shh pathway have been linked to developmental diseases and cancer.

Otras notas

N-terminal peptide encoding amino acid residues 25-198.

Forma física

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline, pH 7.4, containing 5% trehalose and 50 μg of bovine serum albumin per 1 μg of cytokine.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable