RAB0629
Human GDF2 / Growth/Differentiation Factor 2 ELISA Kit
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About This Item
Código UNSPSC:
41116158
NACRES:
NA.32
En este momento no podemos mostrarle ni los precios ni la disponibilidad Póngase en contacto con el Servicio técnico
reactividad de especies
human
envase
kit of 96 wells (12 strips x 8 wells)
técnicas
ELISA: suitable
entrada
sample type plasma
sample type cell culture supernatant(s)
sample type serum
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 32 pg/mL
standard curve range: 32.77-8000 pg/mL
método de detección
colorimetric
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
Información sobre el gen
human ... GDF2(2658)
Descripción general
The growth differentiation factor 2 (GDF2) gene encodes for bone morphogenic protein 9 (BMP9).[1] GDF2, also known as BMP9, belongs to the BMP family.[2] The GDF2 gene is mapped on the human chromosome at 10q11.22.[3] GDF2/BMP9 protein regulates angiogenesis, modulating tumorigenesis, inhibiting hepatic glucose production, and maintaining basal forebrain cholinergic neurons.[2] It is implicated in the pathogenesis of pulmonary arterial hypertension.[2] Mutations in the GDF2 gene are associated with hereditary hemorrhagic telangiectasia (HHT), an autosomal dominant vascular disorder.[1] The antibody pair provided in this kit recognizes human growth/differentiation factor 2.
Aplicación
For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Palabra de señalización
Warning
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Met. Corr. 1
Código de clase de almacenamiento
8A - Combustible corrosive hazardous materials
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Wei Liu et al.
Genes & diseases, 7(2), 235-244 (2020-03-28)
Bone morphogenetic protein 9 (BMP9) (or GDF2) was originally identified from fetal mouse liver cDNA libraries. Emerging evidence indicates BMP9 exerts diverse and pleiotropic functions during postnatal development and in maintaining tissue homeostasis. However, the expression landscape of BMP9 signaling
Felicia Hernandez et al.
Human genome variation, 2, 15040-15040 (2015-01-01)
Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant vascular disorder caused by mutations in ENG, ACVRL1 and SMAD4, which function in regulating the transforming growth factor beta and bone morphogenetic protein signaling pathways. Symptoms of HHT can be present in
Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.
Saus, et al.
Journal of Psychiatric Research, 44, 971-978 (2018)
Z Yang et al.
Science advances, 6(48) (2020-11-29)
Obesity drives the development of nonalcoholic fatty liver disease (NAFLD) characterized by hepatic steatosis. Several bone morphogenetic proteins (BMPs) except BMP9 were reported related to metabolic syndrome. This study demonstrates that liver cytokine BMP9 is decreased in the liver and
Yan-Man Zhou et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 35(5), 978-993 (2020-01-09)
Bone remodeling is dynamic and is tightly regulated through bone resorption dominated by osteoclasts and bone formation dominated by osteoblasts. Imbalances in this process can cause various pathological conditions, such as osteoporosis. Bone morphogenetic protein 9 (BMP9), a biomolecule produced
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