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Merck

R5145

Sigma-Aldrich

Anti-Rsk1 antibody produced in rabbit

whole antiserum

Sinónimos:

Anti-p90rsk

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About This Item

Número MDL:
Código UNSPSC:
12352203
NACRES:
NA.44

origen biológico

rabbit

conjugado

unconjugated

forma del anticuerpo

whole antiserum

tipo de anticuerpo

primary antibodies

clon

polyclonal

mol peso

antigen 80 kDa

contiene

15 mM sodium azide

reactividad de especies

mouse, rat, human

técnicas

microarray: suitable
western blot: 1:4,000 using mouse NIH 3T3 fibroblast cell lysate and rat brain extract

Nº de acceso UniProt

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

Descripción general

Ribosomal S6 kinase 1(Rsk1) is a ubiquitously expressed, mitogen-activated protein that belongs to the serine/threonine protein kinases family. Several isoforms of Rsk have been cloned from mouse (Mo1 and Mo2) 4, 5 and human (HU1-3) source. All of these isoforms encode proteins with calculated molecular masses of about 70 kDa. Their apparent higher masses (90 kDa) may be due to hyperphosphorylation after activation.

Inmunógeno

Synthetic peptide corresponding to amino acids 707-723 of human Rsk1 coupled to KLH.

Aplicación

Anti-Rsk1 antibody can be used in microarray and western blotting.

Acciones bioquímicas o fisiológicas

Ribosomal S6 kinase 1(Rsk1) is regulated via separate signal transduction pathways in response to mitogenic stimulation. It is an important component in nuclear signaling processes. Activation of p90rsk occurs rapidly through phosphorylation of Thr396 located in the kinase catalytic domain. Rsk can phosphorylate and regulate the activity of other molecules such as transcription factor c-fos.
Rsk1 has a pivotal role in facilitating MEK-MAP kinase cell survival signaling and supressing pro-apoptotic function of BAD by phosphorylating . Anti-Rsk1 antibody can be used for studying differential tissue expression of (p90rsk) and its intracellular localization in normal and neoplastic tissues. It can also be used to detect (p90rsk).

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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The RSK factors of activating the Ras/MAPK signaling cascade
Carriere A, et al.
Frontiers in Bioscience, 13(10), 4258-4275 (2008)
Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity
Roux PP, et al.
Molecular and Cellular Biology, 23(14), 4796-4804 (2003)
P70 S6 kinase mediates tau phosphorylation and synthesis
Pei JJ, et al.
Febs Letters, 580(1), 107-114 (2006)
Role of p90rsk in kidney and other diseases
Lin L, et al.
International Journal of Molecular Sciences, 20(4), 972-972 (2019)
A Shimamura et al.
Current biology : CB, 10(3), 127-135 (2000-02-19)
Growth factors activate an array of cell survival signaling pathways. Mitogen-activated protein (MAP) kinases transduce signals emanating from their upstream activators MAP kinase kinases (MEKs). The MEK-MAP kinase signaling cassette is a key regulatory pathway promoting cell survival. The downstream

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