Q2763

Quinalizarin

≥95% (HPLC), powder, plasmodium falciparum casein kinase 2α (PfCK2α) inhibitor

• Sinónimos: 1,2,5,8-Tetrahydroxy-9,10-anthraquinone, 1,2,5,8-Tetrahydroxyanthraquinone, Alizarin Bordeaux BD, Alizarinbordeaux, Alizarine Bordeaux, Alizarine Bordeaux B, C.I. 58500, C.I. Mordant Violet 26, Khinalizarin, NSC 144046, NSC 4896, PHF 016
• Fórmula empírica (notación de Hill): C₁₄H₈O₆
• Número CAS: 81-61-8
• Peso molecular: 272.21
• UNSPSC Code: 12171500
• NACRES: NA.77
• PubChem Substance ID: 329823863
• EC Number: 201-366-6
• MDL number: MFCD00001205
• Colour Index Number: 58500
• Beilstein/REAXYS Number: 1889617
• Assay: ≥95% (HPLC)
• Form: powder

Propiedades

• Nombre del producto: Quinalizarin, ≥95% (HPLC)
• assay: ≥95% (HPLC)
• form: powder
• color: red
• mp: ≥300 °C
• storage temp.: room temp
• SMILES string: Oc1ccc2C(=O)c3c(O)ccc(O)c3C(=O)c2c1O
• InChI: 1S/C14H8O6/c15-6-3-4-7(16)11-10(6)12(18)5-1-2-8(17)13(19)9(5)14(11)20/h1-4,15-17,19H
• InChI key: VBHKTXLEJZIDJF-UHFFFAOYSA-N

Descripción

Application

Quinalizarin has been used:

• as a casein kinase II (CKII) inhibitor to study its effect on CKII-mediated phosphorylation of importin α on subcellular scaling in sperm chromosomes and egg extract[1]
• as a CKII inhibitor to study its ability to block parasite multiplication in a [3H]-hypoxanthine incorporation assay[2]
• to study its effect on colorectal cancer (CRC) cell cycle arrest, cell apoptosis, and reactive oxygen species (ROS) generation in SW480 and HCT-116 cell lines[3]

Biochem/physiol Actions

Quinalizarin is a potent (IC50 = 110 nM), ATP-competitive, and highly selective (IC50 >1μM against CK1 and 72 other kinases) casein Kinase II (CK2) inhibitor.

Quinalizarin is a potent, ATP-competitive, and highly selective casein Kinase II (CK2) inhibitor.

Studies show that quinalizarin can prevent the in vitro activity of recombinant Plasmodium falciparum casein kinase 2α (PfCK2α) catalytic subunit with an IC50 of 2μM.[2]

Información de seguridad

• pictograms: GHS07,GHS09
• signalword: Warning
• hcodes: H302,H410
• pcodes: P264 - P270 - P273 - P301 + P312 - P391 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable