PZ0005

Voriconazole

≥98% (HPLC), powder, ergosterol synthesis inhibitor

• Sinónimos: 2R,3S-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol, UK-109496
• Fórmula empírica (notación de Hill): C₁₆H₁₄F₃N₅O
• Número de CAS: 137234-62-9
• Peso molecular: 349.31
• Número MDL: MFCD00905717
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329823674
• NACRES: NA.77

Propiedades

• product name: Voriconazole, ≥98% (HPLC)
• Análisis: ≥98% (HPLC)
• formulario: powder
• color: white
• solubilidad: DMSO: >20 mg/mL
• temp. de almacenamiento: room temp
• cadena SMILES: C[C@@H](c1ncncc1F)[C@](O)(Cn2cncn2)c3ccc(F)cc3F
• InChI: 1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1
• Clave InChI: BCEHBSKCWLPMDN-MGPLVRAMSA-N

Descripción

Descripción general

Voriconazole is a triazole and a synthetic derivative of fluconazole.

Aplicación

Voriconazole has been used:

• as a control and Erg11 inhibitor in YPD medium
• as a reference drug to test the activity of essential oils against clinical strains of Candida sp.
• as an antifungal agent to test its interactions with valproic acid (VPA)
• to compare its in vitro antifungal activity with essential oils and its components against Cryptococcus neoformans azole-susceptible and not-susceptible clinical isolates

Acciones bioquímicas o fisiológicas

Voriconazole is an antifungal used to treat serious fungal infections. Voriconazole inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-α sterol demethylase resulting in a depletion of ergosterol in fungal cell membranes.

Voriconazole is used to treat invasive aspergillosis (IA). It is vigorous against Candida species, including the strains of Candida albicans, which shows resistance to fluconazole.

Información de seguridad

• Pictogramas: GHS06,GHS08
• Palabra de señalización: Danger
• Frases de peligro: H301,H341,H351,H361,H371,H372,H373,H412
• Consejos de prudencia: P202 - P260 - P264 - P273 - P280 - P301 + P310
• Clasificaciones de peligro: Acute Tox. 3 Oral - Aquatic Chronic 3 - Carc. 2 - Muta. 2 - Repr. 2 - STOT RE 1 - STOT RE 2 Oral - STOT SE 2 Oral
• Órganos de actuación: Eyes, Liver,Kidney
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable