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P7903

Sigma-Aldrich

Pipemidic acid

Sinónimos:

8-Ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)pyrido(2,3-d)pyrimidine-6-carboxylic acid

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About This Item

Fórmula empírica (notación de Hill):
C14H17N5O3
Número de CAS:
51940-44-4
Peso molecular:
303.32
Número CE:
257-530-2
Número MDL:
MFCD00057291
Código UNSPSC:
51282938
ID de la sustancia en PubChem:
24898889
NACRES:
NA.85

formulario

powder

espectro de actividad antibiótica

Gram-negative bacteria
Gram-positive bacteria

Modo de acción

DNA synthesis | interferes
cell wall synthesis | interferes
enzyme | inhibits

cadena SMILES

CCN1C=C(C(O)=O)C(=O)c2cnc(nc12)N3CCNCC3

InChI

1S/C14H17N5O3/c1-2-18-8-10(13(21)22)11(20)9-7-16-14(17-12(9)18)19-5-3-15-4-6-19/h7-8,15H,2-6H2,1H3,(H,21,22)

Clave InChI

JOHZPMXAZQZXHR-UHFFFAOYSA-N

Información sobre el gen

human ... CYP1A2(1544)

Descripción general

Chemical structure: quinolone

Aplicación

Pipemidic acid is used to study DNA damage and mutagenic activity. It has been used to induce articular lesions in the neonatal mouse and is used to study human lymphocyte blastogenesis and γ-interferon production .

Acciones bioquímicas o fisiológicas

Pipemidic acid modulates (inhibits) bacterial DNA gyrase-dependent processes such as DNA polymerization, (ATP-dependent) DNA supercoiling, and chromosome fragmentation. Pipemidic acid has been shown to induce inhibition of lymphocyte DNA synthesis.

Nota de análisis

Very slightly soluble in water. It dissolves in diluted solutions of acids and of alkali hydroxides.

Otras notas

10g,100g
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place

Pictogramas

Health hazard
GHS08

Palabra de señalización

Danger

Frases de peligro

H317,H334

Clasificaciones de peligro

Resp. Sens. 1 - Skin Sens. 1

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Analytical chemistry, 81(9), 3350-3355 (2009-04-14)
For surface-enhanced Raman scattering (SERS)-based protein identification, immunoassay, and drug screening, metal sandwich substrates bridged by proteins have been created in the present study. The sandwich architectures are fabricated based on a layer-by-layer (LbL) technique. The first gold monolayer is
I Grabnar et al.
International journal of pharmaceutics, 322(1-2), 52-59 (2006-06-30)
Intravesical administration of cytotoxic agents is commonly used in urological practice for treatment of superficial bladder cancer. The leading motive is optimisation of drug delivery near the site of action and reduction of systemic toxicity. Bladder pharmacokinetics is complicated by
Adrián Jaén-Gil et al.
Journal of chromatography. A, 1568, 57-68 (2018-06-19)
The evaluation of wastewater treatment capabilities in terms of removal of water pollutants is crucial when assessing water mitigation issues. Not only the monitoring of target pollutants becomes a critical point, but also the transformation products (TPs) generated. Since these
Quinolone-Induced Arthropathy in the Neonatal Mouse: Morphological Analysis of Articular Lesions Produced by Pipemidic Acid and Ciprofloxacin1
DANIEL A. LINSEMAN, LAURIE A. HAMPTON, et al.
Toxicological Sciences, 28, 59-64 (1995)
Hirofumi Kishi et al.
Nanomaterials (Basel, Switzerland), 8(12) (2018-11-24)
Platinum group metal-free (PGM-free) catalysts based on transition metal-nitrogen-carbon nanomaterials have been studied by a combination of ex situ and in situ synchrotron X-ray spectroscopy techniques; high-resolution Transmission Electron Microscope (TEM); Mößbauer spectroscopy combined with electrochemical methods and Density Functional
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