P6126

(R)-(−)-Phenylephrine hydrochloride

≥99% (titration), powder, α₁-adrenoceptor agonist

• Sinónimos: (R)-(−)-1-(3-Hydroxyphenyl)-2-methylaminoethanol hydrochloride, (R)-(−)-3-Hydroxy-α-(methylaminomethyl)benzyl alcohol hydrochloride
• Fórmula lineal: HOC₆H₄CH(CH₂NHCH₃)OH·HCl
• Número de CAS: 61-76-7
• Peso molecular: 203.67
• Beilstein: 4158948
• Número CE: 200-517-3
• Número MDL: MFCD00012605
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 57654535
• NACRES: NA.77

Propiedades

• Nombre del producto: (R)-(−)-Phenylephrine hydrochloride, powder
• Formulario: powder
• Nivel de calidad: 200
• mp: 143-145 °C (lit.)
• emisor: Johnson & Johnson
• cadena SMILES: OC1=CC([C@H](CNC)O)=CC=C1.Cl
• InChI: 1S/C9H13NO2.ClH/c1-10-6-9(12)7-3-2-4-8(11)5-7;/h2-5,9-12H,6H2,1H3;1H/t9-;/m0./s1
• Clave InChI: OCYSGIYOVXAGKQ-FVGYRXGTSA-N
• Información sobre el gen: human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

Descripción

Descripción general

(R)-(-)-Phenylephrine hydrochloride is an adrenergic agent, which functions as a β-receptor sympathomimetic drug.

Aplicación

(R)-(-)-Phenylephrine hydrochloride has been used:

• in the preparation and culturing of cardiocytes and fibroblasts
• to stimulate myocardial strips to measure slice contraction
• in primary cardiomyocyte culture to show the effect of Kruppel-like factors (KLF) on cardiac hypertrophy in vivo
• to evaluate the pharmacological response of embryonic stem cell (ESC)-derived cardiomyocytes
• to pharmacologically rescue GATA (erythroid transcription factor) binding protein 3 (GATA3) null embryo from early embryonic lethality

Acciones bioquímicas o fisiológicas

α₁-adrenoceptor agonist.

Características y beneficios

This compound is featured on the α1-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302,H317
• Consejos de prudencia: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352
• Clasificaciones de peligro: Acute Tox. 4 Oral - Skin Sens. 1B
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Faceshields, Gloves