P3415

3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester

≥95%, powder

• Sinónimos: N-Succinimidyl 3-(2-pyridyldithio)propionate, SPDP
• Fórmula empírica (notación de Hill): C₁₂H₁₂N₂O₄S₂
• Número de CAS: 68181-17-9
• Peso molecular: 312.36
• Beilstein: 1548137
• Número CE: 269-034-3
• Número MDL: MFCD00009636
• Código UNSPSC: 12352106
• ID de la sustancia en PubChem: 24898409
• NACRES: NC.07

Propiedades

• Análisis: ≥95%
• formulario: powder
• idoneidad de la reacción: reagent type: cross-linking reagent
• mp: 84-86 °C (lit.)
• solubilidad: acetone: 50 mg/mL; DMF: soluble
• grupo funcional: NHS ester
• temp. de almacenamiento: −20°C
• cadena SMILES: O=C(CCSSC1=NC=CC=C1)ON2C(CCC2=O)=O
• InChI: 1S/C12H12N2O4S2/c15-10-4-5-11(16)14(10)18-12(17)6-8-19-20-9-3-1-2-7-13-9/h1-3,7H,4-6,8H2
• Clave InChI: JWDFQMWEFLOOED-UHFFFAOYSA-N

Descripción

Descripción general

3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester (SPDP) is a heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity. It is typically coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). Second coupling specific for molecules containing free sulfhydryl by thiol-disulfide exchange buffered at pH 8.0 (7.5-8.5). Alternately, this reagent may be used as a protected thiolating reagent following initial coupling and reduction of linker. It incorporates four atom linker.

Aplicación

3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester (SPDP) is useful for the preparation of enzyme immunoconjugates and hapten carrier molecule conjugates.
It has been used for antibody conjugation and as a protein cross-linker.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves