According to Section 7 of the SDS, the item should be stored at room temp.
P2116
Pirfenidone
≥97% (HPLC), powder, antifibrotic agent
Sinónimos:
5-Methyl-1-phenyl-2-(1H)-pyridone
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| Talla/SKU | Disponibilidad | Precio |
|---|---|---|
10 mg | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 115,00 € |
50 mg | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 511,00 € |
Acerca de este artículo
Fórmula empírica (notación de Hill):
C12H11NO
Número CAS:
Peso molecular:
185.22
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥97% (HPLC)
Form:
powder
115,00 €
Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
Servicio técnico
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Permítanos ayudarleNombre del producto
Pirfenidone, ≥97% (HPLC)
Quality Segment
assay
≥97% (HPLC)
form
powder
solubility
H2O: >10 mg/mL at 60 °C (warming for 30 minutes), DMSO: >20 mg/mL
originator
Shionogi
SMILES string
O=C(C=CC(C)=C1)N1C2=CC=CC=C2
InChI
1S/C12H11NO/c1-10-7-8-12(14)13(9-10)11-5-3-2-4-6-11/h2-9H,1H3
InChI key
ISWRGOKTTBVCFA-UHFFFAOYSA-N
General description
Pirfenidone (5-methyl-1-phenyl-2-[1H]-pyridone) is a synthetic derivative of pyridine.
Application
Pirfenidone has been used:
- as a post-operative eye drop in rabbits to analyse its antifibrotic effect to improve glaucoma filtration surgery
- as an anti-scarring agent to examine whether it affects the foreign body reaction after glaucoma drainage device (GDD) implantation in a rabbit
- to test its antifibrotic potential in primary cultures of human orbital fibroblasts (hOFs)
- as tumor necrosis factor (TNFα) inhibitor to study its effect in hypoxia
Biochem/physiol Actions
Pirfenidone is used to treat idiopathic pulmonary fibrosis (IPF). It helps to decrease the weakening of lung function decline and ameliorate progression-free survival. Pirfenidone can repress the multiplication and contraction of collagen of human tenon′s fibroblasts.
Inhibits collagen production and fibroblast proliferation.
Pirfenidone inhibits collagen production and fibroblast proliferation. It has shown antifibrotic and anti-inflammatory properties in variety of animal models of pulmonary fibrosis, and in clinical trials.
Features and Benefits
This compound was developed by Shionogi. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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Este artículo | |||
|---|---|---|---|
| description ≥97% (HPLC) | description European Pharmacopoeia (EP) Reference Standard | description ≥98% (HPLC) | description ≥98% (HPLC) |
| assay ≥97% (HPLC) | assay - | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form powder | form - | form powder | form powder |
| Quality Level 100 | Quality Level - | Quality Level 100 | Quality Level 100 |
| solubility DMSO: >20 mg/mL, H2O: >10 mg/mL at 60 °C (warming for 30 minutes) | solubility - | solubility DMSO: >20 mg/mL | solubility H2O: >30 mg/mL |
| originator Shionogi | originator - | originator - | originator Teva |
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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