P0713
Anti-Protein Kinase Cζ antibody produced in rabbit
whole antiserum
Sinónimos:
Anti-PKC ζ
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About This Item
Número MDL:
Código UNSPSC:
12352203
origen biológico
rabbit
conjugado
unconjugated
forma del anticuerpo
whole antiserum
tipo de anticuerpo
primary antibodies
clon
polyclonal
mol peso
antigen 78 kDa
contiene
15 mM sodium azide
reactividad de especies
rat, mouse
técnicas
microarray: suitable
western blot: suitable using rat brain extract and mouse NIH3T3 fibroblast cell lysate
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
Información sobre el gen
mouse ... Prkcz(18762)
rat ... Prkcz(25522)
Descripción general
Protein Kinase C (PKC) is a 76-93 kD phospholipid-dependent enzyme that belongs to serine/threonine protein kinases family. It has a pivotal role in cell growth and differentiation, modulation of neurotransmission, signal transduction and oncogenesis. PKC ζ isoform is expressed mainly in many cells and tissues and is activated by cis- unsaturated fatty acids. Anti-protein kinase C ζ antibody can be used for studying differential tissue expression and intracellular localization of PKC ζ. It can also be used for studying PKC expression in normal and neoplastic tissues. Rabbit anti-protein kinase C ζ antibody reacts specifically with PKC ζ (78 kD) from rat brain extract. The product is also specific for PKC ζ (78-80 kD proteins appearing as doublet) from NIH 3T3 mouse fibroblasts lysate.
Inmunógeno
Synthetic peptide corresponding to the C-terminal variable (V5) region (amino acids 577-592) of PKC ζ coupled to KLH.
Almacenamiento y estabilidad
For continuous use, store at 2-8 °C for up to one month.For extended storage freeze in working aliquots.Repeated freezing and thawing is not recommended.Storage in "frost-free" freezers is not recommended. Ifslight turbidity occurs upon prolonged storage, clarifythe solution by centrifugation before use.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Yimin Zhu et al.
Cellular signalling, 17(9), 1125-1136 (2005-07-05)
Protein kinase C (PKC) is a family of serine/threonine protein kinases that are pivotal in cellular regulation. Since its discovery in 1977, PKCs have been known as cytosolic and peripheral membrane proteins. However, there are reports that PKC can insert
Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramide.
He Q, Wang G, Wakade S, et al.
Molecular Biology of the Cell, 25(11), 1715-1729 (2014)
Y Nishizuka
Science (New York, N.Y.), 258(5082), 607-614 (1992-10-23)
Hydrolysis of inositol phospholipids by phospholipase C is initiated by either receptor stimulation or opening of Ca2+ channels. This was once thought to be the sole mechanism to produce the diacylglycerol that links extracellular signals to intracellular events through activation
Holly E Lovegrove et al.
Development (Cambridge, England), 146(23) (2019-12-01)
The Drosophila egg chamber comprises a germline cyst surrounded by a tightly organised epithelial monolayer, the follicular epithelium (FE). Loss of integrin function from the FE disrupts epithelial organisation at egg chamber termini, but the cause of this phenotype remains
Elena Rainero et al.
PloS one, 9(6), e97144-e97144 (2014-06-03)
Diacylglycerol kinase α (DGKα), by phosphorylating diacylglycerol into phosphatidic acid, provides a key signal driving cell migration and matrix invasion. We previously demonstrated that in epithelial cells activation of DGKα activity promotes cytoskeletal remodeling and matrix invasion by recruiting atypical
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