P0121
Anti-Purinergic Receptor P2X3 antibody produced in rabbit
affinity isolated antibody, lyophilized powder
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
Productos recomendados
origen biológico
rabbit
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
formulario
lyophilized powder
reactividad de especies
rat
técnicas
immunohistochemistry: suitable using rat embryo DRG
western blot: 1:200 using rat dorsal root ganglion (DRG) lysates
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
rat ... P2rx3(81739)
Categorías relacionadas
Descripción general
The P2X3 (purinergic receptor P2X 3) receptor is expressed in primary afferent neurons. It is a subtype of P2X receptors family of ligand-gated ion channels, activated by extracellular ATP (adenosine triphosphate).
Inmunógeno
peptide (C)VEKQSTDSGAYSIGH corresponding to residues 383-397 of rat P2rx3.
Aplicación
Anti-Purinergic Receptor P2X3 antibody has been used in immunohistochemistry.
Acciones bioquímicas o fisiológicas
The P2X3 (purinergic receptor P2X 3) plays a major role in the transmission of pain. Inducing P2X3 generates a desensitizing transient response and initiating P2X2/3 creates a relatively persistent response. P2X3 decreases the sympathetic tone in SH rats.
Descripción de destino
The P2X3 receptor is highly expressed on nociceptive sensory neurons in dorsal root ganglia (DRG) as a homomer or as a heteromer (P2X3/P2X2). ATP released from damaged cells activates the P2X3 receptor to initiate nociceptive signals. Involvement of ATP in the mechanism of chronic pain contributes to P2X3 receptor as a possible target for the development of pain therapeutics.
Forma física
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.05% sodium azide.
Reconstitución
Reconstitute the lyophilized vial with 50 μL or 200 μL deionized water, depending on package size. Further dilutions should be made using a carrier protein such as BSA (1-3%).
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 2
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Wang S, et al.
Purinergic Signaling, 12(1), 139-148 (2016)
S Kambiz et al.
Experimental neurology, 267, 87-94 (2015-03-10)
Mirror-image pain is a phenomenon in which unprovoked pain is detected on the uninjured contralateral side after unilateral nerve injury. Although it has been implicated that enhanced production of nerve growth factor (NGF) in the contralateral dorsal root ganglion is
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