N6909

Neurturin human

>95% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

• Sinónimos: NRTN, NTN
• Número MDL: MFCD01867712
• Código UNSPSC: 51111800

Propiedades

• origen biológico: human
• recombinante: expressed in E. coli
• Ensayo: >95% (SDS-PAGE)
• Formulario: lyophilized powder
• potencia: 15-50 ng/mL ED₅₀
• mol peso: monomer calculated mol wt ~12.5 kDa; predicted mol wt ~14 kDa by SDS-PAGE (reducing)
• condiciones de almacenamiento: avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)
• impurezas: endotoxin, tested
• Nº de acceso UniProt: Q99748
• temp. de almacenamiento: −20°C
• Información sobre el gen: human ... NRTN(4902)

Descripción

Acciones bioquímicas o fisiológicas

Member of the glial cell line-derived neurotrophic factor family of ligands. Exerts potent effects on the function and survival of central and peripheral neurons. Activates the RET receptor tyrosine kinase, MAP kinase, and phosphatidylinositol 3-kinase pathways.

Member of the glial cell line-derived neurotrophic factor family of ligands. Exerts potent effects on the function and survival of central and peripheral neurons. Activates the RET receptor tyrosine kinase, MAP kinase, and phosphatidylinositol 3-kinase pathways. Human and mouse NTN share 91% sequence identity.

Forma física

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA containing 1.25 mg bovine serum albumin.

Nota de análisis

The biological activity is measured by its ability to bind recombinant human GFRα2/Fc.

Información de seguridad

• Código de clase de almacenamiento: 13 - Non Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)