N3539

Nicorandil

≥98% (HPLC)

• Sinónimos: 2-(Pyridine-3-carbonylamino)ethyl nitrate, 2-Nicotinamidoethyl nitrate, Ikorel, N-[2-(Nitrooxy)ethyl]-3-pyridinecarboxamide, SG-75, Sigmart, Zynicor
• Fórmula empírica (notación de Hill): C₈H₉N₃O₄
• Número de CAS: 65141-46-0
• Peso molecular: 211.17
• Número CE: 265-514-1
• Número MDL: MFCD00186520
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329818637
• NACRES: NA.77

Propiedades

• Análisis: ≥98% (HPLC)
• formulario: powder
• color: white to off-white
• solubilidad: DMSO: >10 mg/mL
• temp. de almacenamiento: room temp
• cadena SMILES: [O-][N+](=O)OCCNC(=O)c1cccnc1
• InChI: 1S/C8H9N3O4/c12-8(7-2-1-3-9-6-7)10-4-5-15-11(13)14/h1-3,6H,4-5H2,(H,10,12)
• Clave InChI: LBHIOVVIQHSOQN-UHFFFAOYSA-N

Descripción

Aplicación

Nicorandil has been used as an activator of potassium (K⁺) channel and inhibitor of voltage-gated calcium channel to study its effects on action potentials in long QT syndrome 2 (LQTS2) human induced pluripotent stem cell (hiPSCs)-derived cardiomyocytes.

Acciones bioquímicas o fisiológicas

Nicorandil exhibits cardio-protective effects.

Nicorandil is a hybrid ATP-sensitive K+ (KATP) channel opener and nicotinamide nitrate NO donor. Nicorandil selectively activates SUR2B- versus SUR2A-containing KATP channels. It enhances endothelial NO synthase expression and protects against ischemic ventricular arrhythmias. By activating potassium channels, and donating nitric oxide to activate the enzyme guanylate cyclase, Nicorandil causes activation of GMP leading to both arterial and venous vasodilatation. Nicorandil is selective for vascular potassium channels, but has no significant action on cardiac contractility and conduction.

Características y beneficios

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Pictogramas: GHS02,GHS07
• Palabra de señalización: Danger
• Frases de peligro: H242,H302
• Consejos de prudencia: P210 - P235 - P280 - P301 + P312 - P370 + P378 - P410
• Clasificaciones de peligro: Acute Tox. 4 Oral - Org. Perox. D
• Código de clase de almacenamiento: 5.2 - Organic peroxides and self-reacting hazardous materials
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves