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Merck
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MAK328

Sigma-Aldrich

Arginase Inhibitor Screening Kit

sufficient for 100 colorimetric tests

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About This Item

Código UNSPSC:
12161503

uso

sufficient for 100 colorimetric tests

método de detección

colorimetric

enfermedades relevantes

cardiovascular diseases; neurological disorders

Descripción general

Arginase (L-arginine ureohydrolase) is present in mammals and plants. In humans, arginase is expressed predominantly in the liver, and to lesser degrees in breast, kidney, testes, salivary glands, epidermis and erythrocytes. Arginase catalyzes the conversion of arginine to ornithine and urea, important for protection against NH3 toxicity and for cell growth and repair. Excessive arginase activity has been linked to cardiovascular diseases, also contribute to vascular structural problems and neural toxicity. Studies show that arginase inhibitors have been proven to be beneficial in cardiovascular and nervous system diseases. Simple, direct and automation-ready procedures for measuring arginase inhibition are highly desirable in Research and Drug Discovery.

Características y beneficios

Compatible with high-throughput handling systems.

Idoneidad

Suitable for inhibitor screening and evaluation of Arginase inhibitors.

Principio

The Arginase Inhibitor Screening Kit provides a sensitive and convenient method to screen for arginase inhibitors. The method utilizes a chromogen that forms a colored complex specifically with urea produced in the arginase reaction. The intensity of the color is directly proportional to the arginase activity in the sample. Percent inhibition of a test compound can be determined by comparing the color intensity of the reaction preincubated with the test compound with the color intensity of an untreated control reaction.

Otras notas

For additional information on our range of Biochemicals, please complete this form.

Pictogramas

Health hazardCorrosion
GHS08,GHS05

Palabra de señalización

Danger

Frases de peligro

H290,H314,H360FD,H412

Clasificaciones de peligro

Aquatic Chronic 3 - Eye Dam. 1 - Met. Corr. 1 - Repr. 1B - Skin Corr. 1A

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

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