The gene Kcnh8 (potassium voltage-gated channel subfamily H member 8), also referred to as Elk1/Ets-1, belongs to the Ets family of transcription factors. The members of this subfamily are part of the ether-a-go-go (EAG) family of potassium channel pore-forming subunits. The rat elk mRNA is found to be expressed in brain. The rat elk subunits contain six hydrophobic membrane-spanning segments S1-S6, a P-domain, and a motif homologous to cyclic nucleotide-binding domains at the C-terminus.
Inmunógeno
peptide EDKKEDRAKGRSRAG(C) corresponding to amino acid residues 143-157 of rat KV12.1.
Acciones bioquímicas o fisiológicas
The gene Kcnh8 (potassium voltage-gated channel subfamily H member 8) encodes a potassium channel pore-forming subunit that activates p21WAF1/Cip1 via cis-acting elements in p21WAF1/Cip1 and inhibits apoptosis of vascular smooth muscle cells. The potassium channel is found to mediate slowly activating sustained potassium currents.
Descripción de destino
Kv12.1 channel is confined mainly to the central nervous system with some expression in peripheral organs such as testis, colon and lung. The physiological function of the Kv12.1 channel hasn′t been established, although a role in the modulation of overall excitability of neurons has been suggested.
Forma física
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.025% sodium azide.
Reconstitución
Reconstitute the lyophilized vial with 50 μL or 200 μL deionized water, depending on package size. Further dilutions should be made using a carrier protein such as BSA (1-3%).
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Differential expression of genes encoding subthreshold-operating voltage-gated K+ channels in brain.
Saganich MJ
The Journal of Neuroscience, 21, 4609-4624 (2001)
Cloning and functional expression of rat ether-a-go-go-like K+ channel genes.
Engeland B
The Journal of Physiology, 513, 647-654 (1998)
Formate assay in body fluids: application in methanol poisoning.
A B Makar et al.
Biochemical medicine, 13(2), 117-126 (1975-06-01)
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