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Merck

I9657

Sigma-Aldrich

Ionomycin from Streptomyces conglobatus

≥98% (HPLC)

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About This Item

Fórmula empírica (notación de Hill):
C41H72O9
Número de CAS:
Peso molecular:
709.00
Beilstein:
3642126
Número MDL:
Código UNSPSC:
51102829
ID de la sustancia en PubChem:
NACRES:
NA.85

origen biológico

Streptomyces conglobatus

Nivel de calidad

Ensayo

≥98% (HPLC)

solubilidad

acetonitrile: 10 mg/mL

espectro de actividad antibiótica

Gram-positive bacteria

Modo de acción

cell membrane | interferes

temp. de almacenamiento

−20°C

cadena SMILES

C[C@H](CCC(O)=O)C[C@H](C)C[C@H](C)C(=O)\C=C(/O)[C@H](C)C[C@H](C)C\C=C\[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]1CC[C@](C)(O1)[C@H]2CC[C@](C)(O2)[C@@H](C)O

InChI

1S/C41H72O9/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47)/b13-11+,34-24-/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+/m1/s1

Clave InChI

PGHMRUGBZOYCAA-ADZNBVRBSA-N

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Aplicación

Ionomycin from Streptomyces conglobatus has been used:
  • in magnesium-ionomycin treatment experiments
  • as a supplement in calcium-free Dulbecco′s modified Eagle medium (DMEM) for ionophore treatment
  • in the restimulation of peripheral blood mononuclear cells (PBMCs) to analyze cytokine production using flow cytometry (FCM)
  • as a calcium ionophore to treat oocytes to perform intracytoplasmic sperm injection (ICSI) combined with assisted oocyte activation (AOA)

Acciones bioquímicas o fisiológicas

Ionomycin is a polyether antibiotic and an ionophore produced by the bacterium Streptomyces conglobatus. This Ca2+ ionophore is more effective than A23187 as a mobile ion carrier for Ca2+. It is non-fluorescent. It induces apoptotic degeneration of embryonic cortical neurons. Ionomycin has been shown to induce central demyelination, inhibit adrenal bovine TREK-1 channels, and regulate cell division of mature human B cells. It is used to study the effects of calcium flux on endoplasmic reticulum (ER) stress, mitochondrial stress, and intrinsic apoptosis mechanisms. It also stimulates the intracellular production of cytokines, interferon, perforin, interleukin-2 (IL-2), and IL-4 usually in conjunction with PMA.
Ionomycin is highly specific for divalent cations. It may have antiproliferative effects on the human bladder cancer cell line both in vitro and in vivo. Ionomycin functions as an apoptosis inducer which was suggested to act by activation of a latent, calcium-responsive endonuclease.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves


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Fertility and sterility, 112(2), 266-274 (2019-05-28)
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