I5532

Anti-Interleukin-21 Receptor, N-Terminal antibody produced in rabbit

~0.5 mg/mL, affinity isolated antibody, buffered aqueous solution

• Sinónimos: Anti-IL-21R
• UNSPSC Code: 51111800
• MDL number: MFCD03455325

Propiedades

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~60 kDa
• species reactivity: human
• concentration: ~0.5 mg/mL
• technique(s): western blot: 0.5-1 μg/mL
• UniProt accession no.: Q9HBE5
• shipped in: dry ice
• storage temp.: −20°C
• Gene Information: human ... IL21R(50615)

Descripción

Immunogen

synthetic peptide corresponding to amino acids 20-32 of human IL-21 receptor precursor.

Biochem/physiol Actions

Interleukin-21 (IL-21) is a cytokine that regulates both innate and adaptive immunity. The biological effects of IL-21 are mediated by a heterodimeric receptor made up of IL-21R and a γ chain subunit. IL-21R is expressed in liver, thymus, dendritic cells , lymph nodes and spleen. Binding of IL-21 to the receptor leads to activation of JAK (JAK1 and JAK3), STAT (STAT1, 3, 4 and 5) proteins. IL-21R is important for sustained T cell responses during chronic viral infections, production of interferons against pathogens and protection against tumor formation.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.