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Merck
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I2386

Sigma-Aldrich

Anti-Human IgM (μ-chain specific) antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Sinónimos:

Anti-IgM produced in Goat, Goat Anti-Human IgM, IgM Detection Antibody

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About This Item

Número MDL:
MFCD00162459
Código UNSPSC:
12352203
NACRES:
NA.46

origen biológico

goat

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

secondary antibodies

clon

polyclonal

formulario

buffered aqueous solution

técnicas

indirect ELISA: 1:20,000-1:40,000

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

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Descripción general

IgM antibodies are present as pentamers in the serum and are produced in response to antigens.

Aplicación

Anti-Human IgM (μ-chain specific) antibody produced in goat has been used in enzyme linked immunosorbent assay (ELISA).

Acciones bioquímicas o fisiológicas

Immunoglobulin M (IgM) antibodies are the primary ones to be produced in response to antigen. They bind with low affinity but exhibit a broad specificity to a variety of antigens. IgM constitutes 15% of adult immunoglobulins. IgM is important for fetal and neonatal host defenses for several reasons. IgM molecule efficiently activates classical pathway of complement. Its pentameric structure helps in accomodating multivalent ligand binding. IgM has a prominent role in clearance of invading microorganisms from serum.

Forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Anti-protein immunoglobulin M responses to pneumococcus are not associated with aging
German EL, et al.
Pneumonia (Nathan Qld.), 10(1), 5-5 (2018)
J Ollila et al.
Genes and immunity, 4(5), 343-350 (2003-07-09)
The development of adaptive immunity and responses to foreign molecules and organisms relies on the highly regulated production of hundreds of proteins. B-cell maturation, from committed progenitors to terminally differentiated plasma cells, is a multistep process that requires the ordered
Fredy Brice Nemg Simo et al.
Intervirology, 61(6), 265-271 (2019-05-03)
On May 2017, a case of dengue serotype 1 was detected and confirmed through routine surveillance in a traveler returning from Kribi, a seaside town of Southern Cameroon. This study aimed at confirming the circulation of dengue virus (DENV) in
Yang Li et al.
Cell reports, 34(13), 108915-108915 (2021-03-25)
To fully decipher the immunogenicity of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike protein, it is essential to assess which part is highly immunogenic in a systematic way. We generate a linear epitope landscape of the Spike protein
Johannes U Ammann et al.
Current protocols in protein science, 75, 19-19 (2014-02-11)
Discovery of binding partners for immunoglobulin molecules expressed by cells of the immune system is an important topic of current research. However, many ligand-receptor interactions are of low affinity, and hence detection is refractory to most established protocols. We evaluated
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