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I1646

Sigma-Aldrich

IL-3 human

≥97% (HPLC and SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sinónimos:

Interleukin-3 human, hIL-3, IL-3

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10 μG
523,00 €
50 μG
691,00 €

523,00 €

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10 μG
523,00 €
50 μG
691,00 €

About This Item

Número MDL:
MFCD00147276
Código UNSPSC:
12352202
NACRES:
NA.77

523,00 €

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Nombre del producto

Interleukin-3 human, IL-3, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

origen biológico

human

Nivel de calidad

200

recombinante

expressed in E. coli

Ensayo

≥97% (HPLC and SDS-PAGE)

Formulario

lyophilized powder

potencia

≤1.0 ng/mL ED50/EC50

calidad

endotoxin tested

mol peso

15 kDa

envase

pkg of 10 and 50 μg

condiciones de almacenamiento

avoid repeated freeze/thaw cycles

técnicas

cell culture | mammalian: suitable

impurezas

≤0.1 EU/μg

Nº de acceso UniProt

P08700

temp. de almacenamiento

−20°C

Información sobre el gen

human ... IL3(3562)

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Categorías relacionadas

Acciones bioquímicas o fisiológicas

Interleukin-3 (IL-3) is a multifunctional protein, originally called colony forming unit-stimulating activity (CFU-SA), and is produced by activated T lymphocytes. IL-3 supports the formation of multilineage colonies in the early development of multipotent hematopoietic progenitor cells. IL-3 has been shown to induce colony formation of macrophages, neutrophils, mast cells, and megakaryocytes from agar-suspended bone marrow cells. IL-3 also interacts with IL-2 to stimulate growth of T lymphocytes and to induce IgG secretion from activated B cells. Other synonyms for IL-3 include pan-specific hemopoietin, multicolony stimulating factor, mast cell growth factor, burst promoting activity, histamine-producing cell stimulating factor, P cell stimulating factor, and WEHI-3 factor.
Interleukin-3 is a multifunctional protein produced by activated T lymphocytes. IL-3 supports the formation of multilineage colonies in the early development of multipotent hematopoietic progenitor cells. IL-3 also interacts with IL-2 to stimulate growth of T lymphocytes and induce IgG secretion from activated B cells.

Forma física

Lyophilized with no additives. Sterile filtered through a 0.2 μm filter.

Nota de análisis

The biological activity is measured by the dose-dependent stimulation of the proliferation of human TF-1 cells.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
SLCQ6998
SLBV4803
SLCN6209
SLCP5482
SLCL6950

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Bingrui Wang et al.
Cell discovery, 8(1), 41-41 (2022-05-10)
Ribosomal protein dysfunction causes diverse human diseases, including Diamond-Blackfan anemia (DBA). Despite the universal need for ribosomes in all cell types, the mechanisms underlying ribosomopathies, which are characterized by tissue-specific defects, are still poorly understood. In the present study, we
Ding Wang et al.
iScience, 26(6), 106917-106917 (2023-06-28)
The role of SET domain containing 7 (SETD7) during human hematopoietic development remains elusive. Here, we found that deletion of SETD7 attenuated the generation of hematopoietic progenitor cells (HPCs) during the induction of hematopoietic differentiation from human embryonic stem cells
S Yousefi et al.
Allergy, 70(9), 1184-1188 (2015-06-05)
Basophils are primarily associated with immunomodulatory functions in allergic diseases and parasitic infections. Recently, it has been demonstrated that both activated human and mouse basophils can form extracellular DNA traps (BETs) containing mitochondrial DNA and granule proteins. In this report
Amy H Lin et al.
Journal of virology, 88(17), 10066-10077 (2014-06-27)
We developed a Moloney mouse leukemia virus (MLV)-based retroviral replicating vector (RRV), Toca 511, which has displayed tumor specificity in resected brain tumor material and blood in clinical trials. Here, we investigated the interaction between Toca 511 and human host
Hai Zhou et al.
Thrombosis and haemostasis, 113(5), 1021-1034 (2015-01-09)
Impaired megakaryocyte maturation and insufficient platelet production have been shown to participate in the pathogenesis of immune thrombocytopenia (ITP). Our previous study demonstrated that low expression of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) in megakaryocytes contributed to impaired platelet production
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