H6541
Oncostatin M human
OSM, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
Sinónimos:
OSM
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10 μG
451,00 €
451,00 €
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10 μG
451,00 €
About This Item
451,00 €
Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
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origen biológico
human
Nivel de calidad
recombinante
expressed in HEK 293 cells
Ensayo
≥95% (SDS-PAGE)
Formulario
lyophilized powder
potencia
≤0.1-1.5 ng/mL EC50
calidad
endotoxin tested
mol peso
dimer 30 kDa (glycosylated)
envase
pkg of 5X10 μg
pkg of 10 μg
técnicas
cell culture | mammalian: suitable
impurezas
≤1 EU/μg
Nº de acceso UniProt
temp. de almacenamiento
−20°C
Información sobre el gen
human ... OSM(5008)
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Acciones bioquímicas o fisiológicas
Oncostatin M (OSM), LIF, G-CSF, IL-6, and CNTF are structurally related members of the same cytokine family sharing similarities in their primary amino acid sequences, predicted secondary structure, and receptor components. OSM is a growth-regulating cytokine, affecting a number of tumor and normal cells. This material was first identified by its ability to inhibit the growth of A375 melanoma cells and other human tumor cells, but not inhibit the growth of normal human fibroblasts. It acts synergistically with TGF β1 to inhibit the proliferation of tumor cells like A375 melanoma cells. It induces an increase in LDL receptor expression and LDL uptake by hepatoma cells. OSM activates synovial fibroblast-like cells to produce urokinase type plasminogen activator. OSM is secreted by macrophages and activated T lymphocytes.
Forma física
Lyophilized from a 0.2 μm filtered solution of 1x PBS.
Nota de análisis
The activity was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells (humanerythroleukemic indicator cell line)
Información legal
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Yuxin Wang et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(42), 16975-16980 (2013-10-02)
The activation of STAT3 by tyrosine phosphorylation, essential for normal development and for a normal inflammatory response to invading pathogens, is kept in check by negative regulators. Abnormal constitutive activation of STAT3, which contributes to the pathology of cancer and
Yu-Fan Chen et al.
Hepatology (Baltimore, Md.), 55(4), 1193-1203 (2011-11-19)
Liver transplantation is the only definitive treatment for end-stage cirrhosis and fulminant liver failure, but the lack of available donor livers is a major obstacle to liver transplantation. Recently, induced pluripotent stem cells (iPSCs) derived from the reprogramming of somatic
Huang-Ju Tu et al.
Journal of cellular physiology, 228(5), 983-990 (2012-10-09)
Oncostatin M (OSM) belongs to IL-6 subfamily and is mostly produced by T lymphocytes. High levels of OSM are detected in the pannus of rheumatoid arthritis (RA) patients and it may arouse the inflammation responses in joints and eventually leads
Mong-Lien Wang et al.
Cancer research, 72(22), 6051-6064 (2012-11-10)
Mesenchymal stem cells (MSC) are strongly associated with tumor progression and have been used as novel cell-based agents to deliver anticancer drugs to tumors. However, controversies about the direct involvement of MSCs in tumor progression suggest that MSCs mediate tumor
Sema Becerik et al.
Journal of periodontology, 83(10), 1304-1313 (2012-01-18)
The aim of the present study is to investigate gingival crevicular fluid (GCF) and plasma acute-phase cytokines, interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-11 (IL-11), oncostatin M (OSM), and leukemia inhibitory factor (LIF) levels in patients with different periodontal diseases. Eighty individuals
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