F3380
Factor V Activating Enzyme from Russell′s viper venom
lyophilized powder, 20 units/mg protein
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About This Item
Número de CAS:
Número MDL:
Código UNSPSC:
12352204
Productos recomendados
formulario
lyophilized powder
actividad específica
20 units/mg protein
temp. de almacenamiento
−20°C
Aplicación
Factor V activating enzyme from Russell′s viper venom (RVV) is a single-chain glycoprotein that is involved in the rapid clotting of blood. Factor V circulates in the blood as an inactive cofactor and must be activated by proteases such as Factor V activating enzyme from RVV . This product may be useful in studying the blood coagulation cascade as well as the inherited deficiency called parahemophilia .
Acciones bioquímicas o fisiológicas
Factor V activator for RVV contains fucose, mannose, galactose, glucosamine, and neuraminic acid. Factor V activating enzyme from RVV is an arginine esterase that is sensitive to diisopropyl fluorophosphate (DFP) .
Definición de unidad
One unit will increase the Factor V activity in 0.1 mL of fresh normal human plasma by at least 2× after incubation for 3 min at 37 °C.
Forma física
Stabilized in albumin and sodium chloride.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Kenneth Segers et al.
Proteins, 64(4), 968-984 (2006-06-30)
Blood coagulation factor V (FV) is a multifunctional protein that circulates in human plasma as a precursor molecule which can be activated by thrombin or activated factor X (FXa) in order to express its cofactor activity in prothrombin activation. FV
Blood coagulation factors V and VIII: structural and functional similarities and their relationship to hemorrhagic and thrombotic disorders.
W H Kane et al.
Blood, 71(3), 539-555 (1988-03-01)
Rinku Majumder et al.
The Journal of biological chemistry, 286(41), 35535-35542 (2011-08-24)
Constituents of platelet membranes regulate the activity of the prothrombinase complex. We demonstrate that membranes containing phosphatidylcholine and phosphatidylethanolamine (PE) bind factor Va with high affinity (K(d) = ∼10 nm) in the absence of phosphatidylserine (PS). These membranes support formation
Laura M Haynes et al.
Arteriosclerosis, thrombosis, and vascular biology, 32(12), 2877-2883 (2012-10-02)
Rivaroxaban is an oral anticoagulant that directly targets both free factor Xa and factor Xa in complex with its protein cofactor, factor Va, in the prothrombinase complex. It is approved in the United States for the prophylaxis of deep vein
The C-terminus of tissue factor pathway inhibitor α is required for its interaction with factors V and Va.
M Ndonwi et al.
Journal of thrombosis and haemostasis : JTH, 10(9), 1944-1946 (2012-06-29)
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