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F1016

Fenoterol hydrobromide

Name: Fenoterol hydrobromide
Brand: SIGMA

adrenoceptor agonist

Sinónimos:

2-(3,5-Dihydroxyphenyl)-2-hydroxy-2′-(4-hydroxyphenyl)-1′-methyldiethylamine hydrobromide

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Fórmula empírica (notación de Hill):

C₁₇H₂₁NO₄ · HBr

Número CAS:

1944-12-3

Peso molecular:

384.26

NACRES:

NA.77

PubChem Substance ID:

24278431

UNSPSC Code:

41116107

EC Number:

217-742-8

MDL number:

MFCD00079288

Quality level:

100

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Nombre del producto

Fenoterol hydrobromide,

Quality Level

100

originator

Boehringer Ingelheim

SMILES string

Br[H].CC(Cc1ccc(O)cc1)NCC(O)c2cc(O)cc(O)c2

InChI

1S/C17H21NO4.BrH/c1-11(6-12-2-4-14(19)5-3-12)18-10-17(22)13-7-15(20)9-16(21)8-13;/h2-5,7-9,11,17-22H,6,10H2,1H3;1H

InChI key

SGZRQMALQBXAIQ-UHFFFAOYSA-N

Gene Information

human ... ADRB2(154)

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Categorías relacionadas

Bioactive Small Molecules

Bioactive Small Molecule Agonists

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Este artículo	F0050000	Y0002102	F8932
Sigma-Aldrich F1016 Fenoterol hydrobromide	F0050000 Fenoterol hydrobromide	Y0002102 Fenoterol for system suitability	Sigma-Aldrich F8932 Fatostatin hydrobromide
Quality Level 100	Quality Level -	Quality Level -	Quality Level 100
originator Boehringer Ingelheim	originator -	originator -	originator -
Gene Information human ... ADRB2(154)	Gene Information human ... ADRB2(154)	Gene Information human ... ADRB2(154)	Gene Information -

General description

Fenoterol hydrobromide is a sympathomimetic drug. It is used to treat asthma, bronchitis and emphysema. Fenoterol administration might be linked to liver damage. It has anti-inflammatory effects on eosinophil function.

Application

Fenoterol hydrobromide has been used in chromatography-tandem mass spectrometry (LC&-MS-MS) for specific and sensitive detection of β-agonists (BAG).

Biochem/physiol Actions

β₂-adrenoceptor agonist; bronchodilator.

Features and Benefits

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Thermodynamics and docking of agonists to the β(2)-adrenoceptor determined using [(3)H](R,R')-4-methoxyfenoterol as the marker ligand.

Lawrence Toll et al.

Molecular pharmacology, 81(6), 846-854 (2012-03-22)

G protein-coupled receptors (GPCRs) are integral membrane proteins that change conformation after ligand binding so that they can transduce signals from an extracellular ligand to a variety of intracellular components. The detailed interaction of a molecule with a G protein-coupled

Shaken but unstirred? Effects of micronutrients on stress and trauma after an earthquake: RCT evidence comparing formulas and doses.

Julia J Rucklidge et al.

Human psychopharmacology, 27(5), 440-454 (2012-07-12)

To compare two micronutrient (vitamins and minerals) formulas (Berocca™ and CNE™) and assess their impact on emotions and stress related to the 6.3 earthquake on February 22(nd) 2011 in Christchurch, New Zealand. 91 adults experiencing heightened anxiety or stress 2-3 months

Effect of fenoterol stereochemistry on the β2 adrenergic receptor system: ligand-directed chiral recognition.

Krzysztof Jozwiak et al.

Chirality, 23 Suppl 1, E1-E6 (2011-05-28)

The β(2) adrenergic receptor (β(2)-AR) is a model system for studying the ligand recognition process in G protein-coupled receptors. Fenoterol (FEN) is a β(2)-AR selective agonist that has two centers of chirality and exists as four stereoisomers. Radioligand binding studies

Increased response to β₂-adrenoreceptor stimulation augments inhibition of IKr in heart failure ventricular myocytes.

Hegui Wang et al.

PloS one, 7(9), e46186-e46186 (2012-10-03)

Increasing evidence indicates that the rapid component of delayed rectifier potassium current (I(Kr)) is modulated by α- and β-adrenergic stimulation. However, the role and mechanism regulating I(Kr) through β(2)-adrenoreceptor (β-AR) stimulation in heart failure (HF) are unclear. In the present

Modeling of ligand binding to G protein coupled receptors: cannabinoid CB1, CB2 and adrenergic β 2 AR.

Dorota Latek et al.

Journal of molecular modeling, 17(9), 2353-2366 (2011-03-03)

Cannabinoid and adrenergic receptors belong to the class A (similar to rhodopsin) G protein coupled receptors. Docking of agonists and antagonists to CB(1) and CB(2) cannabinoid receptors revealed the importance of a centrally located rotamer toggle switch and its possible

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Número de artículo de comercio global

SKU	GTIN
F1016-1G	04061833611562

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