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Merck
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E7278

Sigma-Aldrich

Anti-S1P2, C-Terminal antibody produced in rabbit

~1 mg/mL, fractionated antiserum, buffered aqueous solution

Sinónimos:

Anti-EDG-5, Anti-Endothelial Cell Differentiation Gene 5

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About This Item

Número MDL:
MFCD02686109
Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

200

conjugado

unconjugated

forma del anticuerpo

fractionated antiserum

tipo de anticuerpo

primary antibodies

clon

polyclonal

formulario

buffered aqueous solution

mol peso

antigen ~42 kDa by SDS-PAGE

reactividad de especies

human

concentración

~1 mg/mL

técnicas

western blot: suitable

Nº de acceso UniProt

O95136

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

Información sobre el gen

human ... S1PR2(9294)

Inmunógeno

synthetic peptide (approximately 2.5 kDa, native) derived from the C-terminal region of the EDG-5/S1P2 receptor.

Aplicación

Anti-S1P2, C-Terminal antibody produced in rabbit is suitable for western blotting.

Acciones bioquímicas o fisiológicas

Sphingosine-1-phosphate receptor 2 (S1PR2 or S1P2) is a human gene encodeing a G protein-coupled receptor. It binds the lipid signaling molecule sphingosine 1-phosphate (S1P) and regulates vascular permeability along with S1P1. Activation of S1P2R in endothelial cells increases vascular permeability. It is a bioactive lysophospholipid capable of inducing a wide spectrum of biological responses. S1P acts as an intercellular mediator by interacting with the endothelial differentiation gene (EDG)/S1P family of G protein-coupled receptors. S1P2 receptor is involved in S1P-induced platelet aggregation and Rho kinase activation. Type 2 diabetes patient responds to S1P.

Forma física

Supplied in phosphate buffered saline, pH 7.3, containing 0.08% sodium azide.

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Código de clase de almacenamiento

10 - Combustible liquids

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Voahanginirina Randriamboavonjy et al.
Basic research in cardiology, 104(3), 333-340 (2009-01-14)
Sphingosine-1-phosphate (S1P) is known to affect platelet responsiveness but the receptor mediating these effects and the mechanisms involved are poorly understood. This study was undertaken to examine S1P receptor expression in human platelets as well as potential changes associated with
Teresa Sanchez et al.
Arteriosclerosis, thrombosis, and vascular biology, 27(6), 1312-1318 (2007-04-14)
S1P acts via the S1PR family of G protein-coupled receptors to regulate a variety of physiological responses. Whereas S1P1R activates G(i)- and PI-3-kinase-dependent signals to inhibit vascular permeability, the related S1P2R inhibits the PI-3-kinase pathway by coupling to the Rho-dependent
Makoto Osada et al.
Biochemical and biophysical research communications, 299(3), 483-487 (2002-11-26)
Sphingosine 1-phosphate (Sph-1-P), a bioactive lysophospholipid capable of inducing a wide spectrum of biological responses, acts as an intercellular mediator, through interaction with the endothelial differentiation gene (EDG)/S1P family of G protein-coupled receptors. In this study, the effects of JTE-013

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