E5391

Ethylenediaminetetraacetic acid tetrasodium salt hydrate

≥99.0%

• Sinónimos: EDTA tetrasodium salt, Edathamil, Tetrasodium ethylenediaminetetraacetate hydrate
• Fórmula lineal: (NaOOCCH₂)₂NCH₂CH₂N(CH₂COONa)₂ · xH₂O
• Número CAS: 194491-31-1
• Peso molecular: 380.17 (anhydrous basis)
• UNSPSC Code: 12352204
• NACRES: NA.83
• PubChem Substance ID: 24894613
• EC Number: 200-573-9
• Beilstein/REAXYS Number: 3861753
• MDL number: MFCD00150025

Propiedades

• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥99.0%
• form: powder
• technique(s): ligand binding assay: suitable
• impurities: Insoluble matter, passes filter test
• input: general use sample(s)
• pH: 11.0-12.0 (0.1 M in H₂O)
• solubility: H₂O: 0.1 M, clear, colorless
• anion traces: chloride (Cl^-): ≤0.05%, sulfate (SO₄^2-): ≤0.01%
• cation traces: Al: ≤0.001%, As: ≤0.0001%, Ba: ≤0.0005%, Bi: ≤0.0005%, Ca: <0.001%, Cd: ≤0.0005%, Co: ≤0.0005%, Cr: ≤0.0005%, Cu: ≤0.0005%, Fe: ≤0.0005%, Li: ≤0.0005%, Mg: ≤0.0005%, Mn: ≤0.0005%, Mo: ≤0.0005%, Ni: ≤0.0005%, Pb: ≤0.0005%, Sr: ≤0.0005%, Zn: ≤0.0005%
• absorption: ≤0.06 at 280 in H₂O at 0.1 M, ≤1.5 at 260 in H₂O at 0.1 M
• application(s): sample preparation
• storage temp.: room temp
• SMILES string: O.[Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC([O-])=O
• InChI: 1S/C10H16N2O8.4Na.H2O/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;;;1H2/q;4*+1;/p-4
• InChI key: GXFFSKMBMYHTAE-UHFFFAOYSA-J

Descripción

Application

EDTA is an inhibitor of metalloproteases, at effective concentrations of 1-10 mM. EDTA acts as a chelator of the zinc ion in the active site of metalloproteases, and can also inhibit other metal ion-dependent proteases such as calcium-dependent cysteine proteases. For use as an anticoagulant, disodium or tripotassium salts of EDTA are most commonly used. The optimal concentration is 1.5 mg per ml of blood.

Used to eliminate enzyme inhibition by traces of heavy metals, and to inhibit enzymes that require divalent cations as cofactors.

Preparation Note

Soluble in water at room temperature up to 1.45 M. The pH of this solution will be approximately 10 to 11 and will be rather viscous.

Información de seguridad

• Pictogramas: GHS08,GHS05,GHS07
• Palabra de advertencia: Danger
• Códigos de peligro: H302 + H332,H318,H373
• Indicaciones de precaución: P260 - P280 - P301 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P314
• Hazard Classifications: Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - STOT RE 2
• Órganos diana: Respiratory Tract
• Clase de almacenamiento: 11 - Combustible Solids
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable
• EPI (equipos de protección individual): dust mask type N95 (US), Eyeshields, Gloves