E3526
Anti-phospho-Elk-1 (pSer383) antibody produced in rabbit
affinity isolated antibody, buffered aqueous glycerol solution
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About This Item
origen biológico
rabbit
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
Formulario
buffered aqueous glycerol solution
reactividad de especies
rat, mouse, human
técnicas
western blot (chemiluminescent): 1:1,000 using Elk-1 fusion protein phosphorylated with purified Erk2
Nº de acceso UniProt
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
phosphorylation (pSer383)
Información sobre el gen
human ... ELK1(2002)
mouse ... Elk1(13712)
rat ... Elk1(314436)
Especificidad
The antibody detects Elk-1 protein only when phosphorylated at Ser383.
Inmunógeno
synthetic phosphopeptide corresponding to residues around phosphorylated Ser383 of human Elk-1.
Aplicación
Anti-phospho-Elk-1 (pSer383) antibody produced in rabbit is suitable for western blotting (chemiluminescent) at a dilution of 1:1,000 using Elk-1 fusion protein phosphorylated with purified Erk2.
Acciones bioquímicas o fisiológicas
ETS domain-containing protein Elk-1 is a protein encoded by the ELK1 gene in humans. It is a member of the Ets family of transcription factors. Elk-1 activation is important for executing its physiologic functions. Its activation is positively associated with ER and with Cyclin D1. Elk1 plays a novel role in controlling cell migration. Elk-1 is involved in a number of important cell processes through the activation of different genes in a number of normal tissues as well as in many malignancies. It is also plays a role in breast neoplasia.
Forma física
Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 μg/ml bovine serum albumin and 50% glycerol.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Aggelos Laliotis et al.
Breast (Edinburgh, Scotland), 22(1), 89-95 (2012-11-07)
Recently an increased interest on Elk1 protein and its role in breast cancer evolution has been noted. This protein is an element of the Ets family of transcription factors and it has been involved in a number of important cell
Rachasak Boonhok et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(25), E3519-E3528 (2016-05-18)
IFN-γ is a major regulator of immune functions and has been shown to induce liver-stage Plasmodium elimination both in vitro and in vivo. The molecular mechanism responsible for the restriction of liver-stage Plasmodium downstream of IFN-γ remains uncertain, however. Autophagy
Zaneta Odrowaz et al.
PLoS genetics, 8(5), e1002694-e1002694 (2012-05-17)
Eukaryotic transcription factors are grouped into families and, due to their similar DNA binding domains, often have the potential to bind to the same genomic regions. This can lead to redundancy at the level of DNA binding, and mechanisms are
Jacqueline F Morris et al.
Human pathology, 44(5), 766-776 (2012-11-02)
Elk-1 is a member of the Ets family of transcription factors, which are identified by a conserved Ets DNA-binding domain that mediates transcriptional regulation at Ets sequence--containing promoters. The activation domain of Elk-1 is important for executing its physiologic functions
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